An overview of membrane transport proteins in Saccharomyces cerevisiae

B André


All eukaryotic cells contain a wide variety of proteins embedded in the plasma and internal membranes, which ensure transmembrane solute transport. It is now established that a large proportion of these transport proteins can be grouped into families apparently conserved throughout organisms. This article presents the data of an in silicio analysis aimed at establishing a preliminary classification of membrane transport proteins in Saccharomyces cerevisiae. This analysis was conducted at a time when about 65% of all yeast genes were available in public databases. In addition to approximately 60 transport proteins whose function was at least partially known, approximately 100 deduced protein sequences of unknown function display significant sequence similarity to membrane transport proteins characterized in yeast and/or other organisms. While some protein families have been well characterized by classical genetic experimental approaches, others have largely if not totally escaped characterization. The proteins revealed by this in silicio analysis also include a putative K+ channel, proteins similar to aquaporins of plant and animal origin, proteins similar to Na+-solute symporters, a protein very similar to electroneural cation-...Continue Reading


Feb 14, 1977·Biochimica Et Biophysica Acta·M L GrethF Lacroute
May 16, 1977·Biochimica Et Biophysica Acta·G M RoomansG W Borst-Pauwels
Dec 1, 1979·Journal of Bacteriology·V Turoscy, T G Cooper
Aug 1, 1979·Molecular & General Genetics : MGG·E Dubois, M Grenson
Jan 1, 1992·Annual Review of Cell Biology·C F Higgins
Jan 1, 1992·International Review of Cytology·R F Gaber
Aug 1, 1992·Current Opinion in Cell Biology·N Nelson
Sep 1, 1992·Molecular and Cellular Biology·D S ConklinC Kung
May 7, 1992·Nature·S G OliverP Benit
Oct 21, 1991·FEBS Letters·R HaroA Rodríguez-Navarro
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A Bertl, C L Slayman
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S L Roberds, M M Tamkun
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G M Preston, P Agre
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A WernerH Murer
Feb 22, 1991·Science·H A HartmannA M Brown
Jun 1, 1991·Molecular and Cellular Biology·M Bun-YaY Oshima
Aug 1, 1991·Molecular and Cellular Biology·C H Ko, R F Gaber
Aug 1, 1990·Trends in Biochemical Sciences·H R KabackP D Roepe
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Nov 1, 1990·Molecular and Cellular Biology·A L Kruckeberg, L F Bisson
Feb 1, 1990·Molecular and Cellular Biology·R F GaberG R Fink
Sep 12, 1986·Science·M C GustinC Kung
Jan 1, 1989·Annual Review of Physiology·M Haas
Jan 1, 1985·Advances in Microbial Physiology·J M WiameH N Arst
Mar 1, 1987·Archives of Biochemistry and Biophysics·A PeñaJ Ramírez
Oct 11, 1988·Nucleic Acids Research·A ShielsJ A Bangham
Jan 15, 1988·European Journal of Biochemistry·R JundM R Chevallier
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J L CelenzaM Carlson
Jun 1, 1987·Molecular & General Genetics : MGG·T NakaoY Anraku
Apr 1, 1987·Journal of Bacteriology·L F BissonD G Fraenkel
Nov 1, 1985·Journal of Bacteriology·Y TamaiY Oshima
Jan 1, 1972·Journal of Bacteriology·R Drillien, F Lacroute
Jan 15, 1974·FEBS Letters·R G McCready, G A Din
Mar 1, 1968·Journal of Bacteriology·F Lacroute
Nov 5, 1968·Biochimica Et Biophysica Acta·G F Fuhrmann, A Rothstein
Dec 15, 1984·Journal of Molecular Biology·K O'HareG M Rubin
Feb 29, 1984·Biochimica Et Biophysica Acta·B J Nieuwenhuis, G W Borst-Pauwels
Sep 1, 1984·Journal of Bacteriology·A Rodríguez-Navarro, J Ramos
Dec 30, 1981·Biochimica Et Biophysica Acta·A Goffeau, C L Slayman
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies
Jan 8, 1981·Biochimica Et Biophysica Acta·A Rodríguez-NavarroC Pérez-Lloveres
Jul 1, 1982·Archives of Biochemistry and Biophysics·E SantosR Sentandreu
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
Oct 1, 1994·Trends in Biochemical Sciences·M J Chrispeels, P Agre
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E H AbrahamH F Cantiello
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D MarkovichH Murer
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·D S YuanR D Klausner
Apr 1, 1995·Physiological Reviews·S SchuldinerM Linial
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·H BusseyA B Barton
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·W K Versaw, R L Metzenberg
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·A KralliK R Yamamoto
Jan 27, 1995·The Journal of Biological Chemistry·C K GarciaJ L Goldstein
Jan 15, 1995·European Journal of Biochemistry·A BerheB L Persson
Dec 1, 1994·Plant Molecular Biology·W B FrommerO Ninnemann
Mar 17, 1995·The Journal of Biological Chemistry·A M Pajor
Jun 1, 1994·Journal of Neurochemistry·S Schuldiner
Aug 1, 1994·The Plant Journal : for Cell and Molecular Biology·W KammerloherA R Schäffner
Sep 30, 1994·Journal of Molecular Biology·M E HuangF Galibert
May 1, 1994·Yeast·H Sychrova, M R Chevallier
Oct 1, 1994·The American Journal of Physiology·M Haas
Jul 1, 1994·Human Molecular Genetics·R G LafrenièreH F Willard
Nov 28, 1994·FEBS Letters·R D Klausner, A Dancis
Jun 29, 1994·Biochimica Et Biophysica Acta·J ReizerM H Saier
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·M P KavanaughA D Miller
Aug 2, 1994·Molecular & General Genetics : MGG·A E Ehrenhofer-MurrayC Sengstag
Sep 1, 1994·Journal of Bacteriology·P ChenJ R Roth
Sep 8, 1994·Nature·L Y Jan, Y N Jan
Aug 30, 1994·Biochimica Et Biophysica Acta·E Balzi, A Goffeau
Aug 30, 1994·Biochimica Et Biophysica Acta·A Rodríguez-NavarroB Garciadeblás
Aug 30, 1994·Biochimica Et Biophysica Acta·J S LolkemaW N Konings
Jun 2, 1994·Nature·B DujonP Bossier
Jul 1, 1993·Trends in Biochemical Sciences·M Linial
Dec 1, 1993·Molecular and Cellular Biology·T L RipmasterJ L Woolford
Jan 1, 1994·Molecular and Cellular Biology·J R PerryJ M Becker
Jan 1, 1994·Journal of Bacteriology·J RamosA Rodríguez-Navarro
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·M van ZeijlB O'Hara
Aug 1, 1993·Journal of Bacteriology·H M ElBerryT G Cooper
Jan 1, 1993·Protein Science : a Publication of the Protein Society·J ReizerM H Saier
Jan 1, 1993·Critical Reviews in Biochemistry and Molecular Biology·L F BissonD A Lewis
Oct 1, 1993·Journal of Bacteriology·M KammlerK Hantke
Jan 1, 1993·Molecular and Cellular Biology·C H KoR F Gaber
Jan 18, 1993·Biochimica Et Biophysica Acta·G W Borst-Pauwels
Jan 18, 1993·Biochimica Et Biophysica Acta·G F Fuhrmann, B Völker
Feb 1, 1993·Journal of General Microbiology·L BeijerL Rutberg
Jan 1, 1993·Molecular & General Genetics : MGG·B GarciadeblasA Rodríguez-Navarro
Jan 1, 1993·Trends in Biochemical Sciences·M D Marger, M H Saier


Jul 1, 1996·Nucleic Acids Research·U GüldenerJ H Hegemann
Dec 28, 2002·Genes & Development·Claes Andréasson, P O Ljungdahl
Jan 17, 2003·Plant Physiology·Rainer SchwackeReinhard Kunze
Apr 12, 2001·Plant Physiology·L ChenD R Bush
Apr 17, 2009·Canadian Journal of Microbiology·William E CourchesneSha Liao
Feb 5, 2003·Genome Research·Jochen FörsterJens Nielsen
Oct 9, 2007·The International Journal of Biochemistry & Cell Biology·Jinnie M Garrett
Apr 15, 2004·Biotechnology and Bioengineering·S MalherbeJ-M Sablayrolles
Feb 15, 2005·Fungal Genetics and Biology : FG & B·Alex A AppiahNeil A R Gow
Sep 15, 2004·Gene·Tiziana LodiClaudia Donnini
Dec 24, 2003·Analytical Biochemistry·Dennis W JungDouglas R Pfeiffer
Dec 31, 2003·Biochemical and Biophysical Research Communications·J Schreve, Jinnie M Garrett
Apr 21, 1999·Biochimica Et Biophysica Acta·E Enríquez-FreireA Peña
Apr 5, 2014·Journal of Amino Acids·Daniel A SáenzCarlos A Stella
Feb 4, 2014·FEMS Microbiology Reviews·Michaela ConradJ M Thevelein
Sep 6, 2007·FEMS Microbiology Reviews·Areti Pantazopoulou, George Diallinas
Mar 27, 1999·Biochemical and Biophysical Research Communications·V LaizéF Tacnet
Dec 8, 2004·Biochimica Et Biophysica Acta·Hein TripArnold J M Driessen
Feb 8, 2003·Annual Review of Biophysics and Biomolecular Structure·Reiner Peters
Dec 13, 2006·FEMS Yeast Research·Enrico BaruffiniTiziana Lodi
Oct 24, 2009·FEMS Yeast Research·Marta Rubio-TexeiraJ M Thevelein
May 15, 2007·FEMS Yeast Research·Tiziana LodiPhilippe V Baret
May 2, 2001·Bioscience, Biotechnology, and Biochemistry·A KosugiS Udaka
Sep 21, 2004·Annual Review of Plant Biology·Sylvie LalondeW B Frommer
Jun 28, 2000·Yeast·V LaizéS Hohmann
Dec 31, 1997·The Journal of Biological Chemistry·R WysockiS Ułaszewski
Dec 31, 1997·The Journal of Biological Chemistry·H C Chang, D R Bush
Jan 28, 2017·Journal of Bioscience and Bioengineering·Tatsunori TaniTakashi Akamatsu
Dec 15, 2000·Biotechnology and Bioengineering·W M vanGulikJ J Heijnen
Jan 23, 2014·The Journal of Biological Chemistry·Kassem GhaddarMartine Prévost
Jul 31, 2008·The New Phytologist·Eva LucicAnnick Brun-Jacob
Nov 5, 2008·Rapid Communications in Mass Spectrometry : RCM·Stefan GanderPaul Jenoe
Dec 9, 2008·Nature Chemical Biology·Griet Van ZeebroeckJ M Thevelein
Oct 23, 2009·Applied Biochemistry and Biotechnology·Linda SundströmLeif J Jönsson
Jul 15, 2000·Acta Microbiologica Et Immunologica Hungarica·P RasporM Skrt
Apr 8, 2006·Physiological Reviews·Olivier Staub, Daniela Rotin
Jan 25, 2011·Archives of Microbiology·William E CourchesneSara Coffee
Nov 3, 2018·Current Protein & Peptide Science·João P Bezerra-NetoAna M Benko-Iseppon
Sep 17, 2019·Science Advances·Yuqin WangShuo Huang
Jan 26, 2020·FEMS Yeast Research·Andreia PachecoMaria João Sousa
Mar 29, 2001·The Journal of Biological Chemistry·R RussnakS L McIntire
Feb 28, 1998·The Journal of Biological Chemistry·M S SkrzypekR C Dickson
Aug 1, 1997·The Journal of Biological Chemistry·F EnjoH Nishimura
Aug 19, 2003·The Journal of Biological Chemistry·Laran T JensenValeria Cizewski Culotta
Jan 7, 1998·Molecular and Cellular Biology·C MarchalD Urban-Grimal
Nov 11, 2019·Nature Communications·George L SunAngela M Belcher
Jan 21, 2000·FEMS Microbiology Reviews·E G ter SchureC T Verrips
Feb 24, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A Werner, R K Kinne
Aug 23, 2018·Antonie van Leeuwenhoek·Fernando Augusto da SilveiraIeso M Castro
Jul 20, 1999·Molecular and Cellular Biology·H KlassonP O Ljungdahl
Aug 1, 1997·FEMS Microbiology Reviews·E Boles, C P Hollenberg
Mar 5, 1998·FEMS Microbiology Letters·R WagnerS Potier
Oct 4, 2000·Physiological Genomics·M S HalleckR A Schlegel
Apr 17, 1999·Molecular and Cellular Biology·I IraquiA Urrestarazu
May 2, 1997·The Journal of Biological Chemistry·R J ReidM A Bjornsti

Related Concepts

Carrier Proteins
Yeast Proteins
Ion Channel
Cell Surface Proteins
Saccharomyces cerevisiae

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.