An overview of multiple sequence alignment.

Current Protocols in Bioinformatics
Victor SimossisJaap Heringa

Abstract

Multiple sequence alignment is perhaps the most commonly applied bioinformatics technique. It often leads to fundamental biological insight into sequence-structure-function relationships of nucleotide or protein sequence families. In this unit, an overview of multiple sequence alignment techniques is presented, covering a history of nearly 30 years from the early pioneering methods to the current state-of-the-art techniques. Methodological and biological issues and end-user considerations, as well as alignment evaluation issues, are discussed.

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Citations

May 18, 2011·Nucleic Acids Research·Jaebum Kim, Jian Ma
Jan 28, 2010·BMC Bioinformatics·Jaebum Kim, Saurabh Sinha
Apr 2, 2015·Current Protocols in Protein Science·Ward G Walkup, Mary B Kennedy

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