An overview of process intensification and thermo stabilization for upscaling of Peste des petits ruminants vaccines in view of global control and eradication

Virusdisease
Mousumi BoraRabindra Prasad Singh

Abstract

Peste des petits ruminants (PPR) has been recognized as a globally distributed disease affecting the small ruminant population. The disease results in severe economic losses mainly to small land holders and low input farming systems. The control of PPR is mainly achieved through vaccination with available live attenuated vaccines. The thermo labile nature of PPR virus poses a major constraint in production of quality vaccines which often results in vaccine failures. The lack of quality vaccine production jeopardize the wide vaccination coverage especially in countries with poor infrastructure due to which PPR persists endemically. The vaccine production system may require augmentation to attain consistent and quality vaccines through efforts of process intensification integrated with suitable stabilizer formulations with appropriate freeze drying cycles for improved thermo tolerance. Manufacturing of live attenuated PPR vaccines during batch cultures might introduce defective interfering particles (DIPs) as a result of high multiplicity of infection (MOI) of inoculums, which has a huge impact on virus dynamics and yield. Accumulation of DIPs adversely affects the quality of the manufactured vaccines which can be avoided through...Continue Reading

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Citations

May 18, 2018·Tropical Animal Health and Production·Mohamed Haji AbdilatifFlorence Kanini Mutua
Dec 17, 2020·Frontiers in Veterinary Science·Enokela S IdogaAlasdair J C Cook
Oct 8, 2019·Biologicals : Journal of the International Association of Biological Standardization·Mousumi BoraRabindra Prasad Singh
Feb 9, 2020·Microbial Pathogenesis·Xue-Xia JiaZhen-Chuan Fan

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