An overview of sleep and circadian dysfunction in Parkinson's disease

Journal of Sleep Research
Susanna MantovaniJohn D O'Sullivan

Abstract

Sleep and circadian alterations are amongst the very first symptoms experienced in Parkinson's disease, and sleep alterations are present in the majority of patients with overt clinical manifestation of Parkinson's disease. However, the magnitude of sleep and circadian dysfunction in Parkinson's disease, and its influence on the pathophysiology of Parkinson's disease remains often unclear and a matter of debate. In particular, the confounding influences of dopaminergic therapy on sleep and circadian dysfunction are a major challenge, and need to be more carefully addressed in clinical studies. The scope of this narrative review is to summarise the current knowledge around both sleep and circadian alterations in Parkinson's disease. We provide an overview on the frequency of excessive daytime sleepiness, insomnia, restless legs, obstructive apnea and nocturia in Parkinson's disease, as well as addressing sleep structure, rapid eye movement sleep behaviour disorder and circadian features in Parkinson's disease. Sleep and circadian disorders have been linked to pathological conditions that are often co-morbid in Parkinson's disease, including cognitive decline, memory impairment and neurodegeneration. Therefore, targeting sleep an...Continue Reading

References

Apr 1, 1992·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J M SenardJ L Montastruc
Nov 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·J J van HiltenR A Roos
Jan 1, 1991·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·E FertlF Waldhauser
Jan 1, 1990·Movement Disorders : Official Journal of the Movement Disorder Society·S A FactorW J Weiner
May 1, 1990·The International Journal of Neuroscience·T Akerstedt, M Gillberg
Apr 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·J G NuttT L Trotman
Jan 1, 1988·Journal of Neurology·W EmserK Schimrigk
Dec 1, 1988·Clinical Neuropharmacology·A J LeesV L Campbell
Mar 1, 1987·Neurology·A E Lang, K Johnson
Dec 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·M C AppsD W Empey
Jul 1, 1984·Neurology·P R MartinS P Markey
Mar 9, 1984·Neuroscience Letters·A Wirz-JusticeC Remé
Nov 2, 1994·JAMA : the Journal of the American Medical Association·A D OxmanG H Guyatt
Jan 1, 1993·Fundamental & Clinical Pharmacology·G MassonO Blin
Aug 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·J J van HiltenR A Roos
Jan 1, 1993·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·E FertlF Waldhauser
Mar 1, 1993·Acta Neurologica Scandinavica·J J van HiltenR A Roos
May 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·J G NuttW R Woodward
Nov 25, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·E TandbergK Karlsen
Jan 26, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·A LazzariniW G Johnson
Aug 19, 1999·Journal of Biological Rhythms·A J LewyR L Sack
Dec 10, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·E TandbergK Karlsen
Feb 22, 2000·Clinical Neuropharmacology·U BonuccelliP Piccini
Mar 25, 2000·Journal of Sleep Research·D B RyeP Gurecki
Jul 19, 2001·Brain : a Journal of Neurology·C Guilleminault, S N Brooks
Aug 2, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·B F BoeveJ E Parisi
Nov 3, 2001·Science·P Maquet
Dec 18, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·T C WetterE Friess
Feb 2, 2002·JAMA : the Journal of the American Medical Association·Douglas E HobsonJonathan Fleming
Mar 14, 2002·Archives of Neurology·William G OndoJoseph Jankovic
Apr 10, 2002·Neurology·I ArnulfY Agid
Apr 18, 2002·Journal of the Neurological Sciences·E K TanM C Wong
May 2, 2002·The Journal of Neuropsychiatry and Clinical Neurosciences·James Parkinson
May 30, 2002·Neurology·M D GjerstadJ P Larsen
Aug 2, 2002·Clinical Neuropharmacology·Bernard Bruguerolle, Nicolas Simon

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Citations

Nov 13, 2018·Current Opinion in Neurology·Clare L Fraser
Jun 8, 2018·Journal of Sleep Research·Dieter Riemann
May 24, 2020·Journal of Parkinson's Disease·E Ray DorseyMichael P McDermott
Jul 1, 2019·Journal of Neural Transmission·Christian R Baumann
Apr 7, 2020·Journal of Parkinson's Disease·José Rafael P Zuzuárregui, Jill L Ostrem
Sep 12, 2020·Disability and Rehabilitation·Elliottnell PerezJoseph M Dzierzewski
Apr 5, 2020·Cells·Simoneide S Titze-de-AlmeidaRicardo Titze-de-Almeida
Oct 9, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·José Rafael P Zuzuárregui, Emmanuel H During
Jul 17, 2019·Bioorganic & Medicinal Chemistry Letters·Younggi Choi, Brian K Raymer
Jul 25, 2019·Contemporary Clinical Trials Communications·J NiklesA Ritchie
Oct 31, 2020·BMC Biology·Snehajyoti ChatterjeeTed Abel
Mar 25, 2021·Journal of American College Health : J of ACH·Rose GhemrawiMostafa Khair
Apr 8, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Hengameh ZahedSimon Little
Apr 30, 2021·Journal of Sleep Research·Masoud TahmasianMojtaba Zarei
Jul 31, 2021·Sleep Medicine Clinics·Carlotta MuttiLiborio Parrino
Aug 15, 2021·NeuroImage·Jiahe ZhangSusan Whitfield-Gabrieli
Jan 14, 2022·Experimental Neurology·Aviv D Mizrahi-KligerHagai Bergman

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