An Overview of the Compounds Tested In Vivo for Leishmania spp. of the Last 5 Years.

Current Medicinal Chemistry
Mabilly Cox Holanda de Barros DiasAna Cristina Lima Leite

Abstract

Leishmaniasis, a still important public health problem, exhibits environmental risk factors such as massive migrations, urbanization, and deforestation. WHO research for Leishmaniasis is mainly focused on the development of new tools, such as diagnostic tests, drugs, and vaccines. During the drug development strategy, only a few compounds were promising and call for further study after the in vitro and in vivo preclinical tests. In this review, our group aimed to highlight the utmost research done during 2014 to 2019 in the fields of natural and synthetic compounds, as well as repurposed drugs and new formulations tested in vivo for Leishmania spp. Based on the literature search, we used the databases MEDLINE, PUBMED, CAPES PERIODIC and ELSEVIER to delineate an interval of the last 5 years of research on each field. Among the natural compounds tested, allicin and a fraction of potato tuber extract showed the most promising antileishmanial activity. Concerning synthetic compounds, quinolines, bornyl ester, thymol, benzoxaborole and nitroimidazole derivatives exhibited encouraging results. Moreover, repositioned alternatives involved combinations with known drugs and monotherapy protocols as well. In these years, new formulations...Continue Reading

Citations

Jun 4, 2021·International Journal of Pharmaceutics·Olga Kammona, Evgenia Tsanaktsidou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Current Opinion in Infectious Diseases
P M Loiseau, C Bories
PLoS Neglected Tropical Diseases
Jair L Siqueira-NetoLucio H Freitas-Junior
European Journal of Medicinal Chemistry
Adnan A BekhitAlaa El-Din A Bekhit
© 2021 Meta ULC. All rights reserved