An overview of the efficacy and safety of systemic treatments for psoriasis in the elderly

Expert Opinion on Biological Therapy
Vito Di Lernia, Mohamad Goldust

Abstract

Psoriasis in elderly patients is considered to be of emerging clinical relevance because of the increase in the aged segment of the population. Psoriasis in such a group raises significant management challenges. There is an age-related immunosuppression, a high frequency of comorbidities, and polypharmacy, which enhances the potential risk of drug interactions or side effects when an additional systemic treatment must be administered. Despite the aging of the general population, clinical studies focusing on treatment of geriatric psoriasis are limited. Patients > 65 years are often not included in randomized clinical trials. As a result, the geriatric population affected by moderate-to-severe psoriasis is usually under-treated. Areas covered: This review focuses on the use of systemic treatments in elderly psoriatic patients and their efficacy and safety data, analyzing the available literature evidences. Expert opinion: Conventional agents should be carefully evaluated in each patient considering the possible organ impairment, comorbidities, concomitant medications and contraindications. Apremilast is an appropriate treatment for elderly patients. Biologics represent a safe option for a long-term management of psoriasis. Etane...Continue Reading

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Citations

Mar 5, 2019·Expert Opinion on Biological Therapy·Kristen M Beck, John Koo
Nov 13, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·M MegnaG Fabbrocini
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Feb 15, 2020·Expert Opinion on Drug Safety·Roberta Di CaprioAnna Balato
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Jun 24, 2021·Digestive Diseases and Sciences·Rajat GargBenjamin Click
Aug 26, 2021·Psoriasis : Targets and Therapy·Murlidhar RajagopalanPravin Banodkar

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