PMID: 8600096Mar 15, 1996Paper

An overview of the initial experience with AK-2123 as a hypoxic cell sensitizer with radiation in the treatment of advanced head and neck cancers

International Journal of Radiation Oncology, Biology, Physics
N G HuilgolA R Mehta

Abstract

AK-2123 (Senazole) is a nitrotriazole with a reported potential for hypoxic cell sensitization. The present study was conducted to evaluate hypoxic cell potentiation in patients with advanced head and neck cancer treated with discontinuous accelerated hyperfractionated radiation. Histologically proven unresectable oro-pharyngeal cancers Stage T3-4, NO-3 and M0 were randomly allocated to receive discontinuous accelerated hyperfractionated radiation alone or with AK-2123. AK-2123 (880 and 990 mg) was administered as an i.v. infusion between the first and second fraction of radiation for 10 days in two groups of patients. Initial response as a surrogate end point has been analyzed for comparison and documented for follow-up status. A 100% complete response was observed in both the AK-2123-treated groups (880 mg and 990 mg), while a 44.4% complete response was observed in the control group. There were no treatment-related deaths. Neurotoxicity was not reported. AK-2123 (Senazole) when administered with discontinuous accelerated hyperfractionated radiation showed a significant potentiation that, therefore, requires further evaluation.

References

Apr 1, 1986·International Journal of Radiation Oncology, Biology, Physics·J OvergaardM Hjelm Hansen
Aug 1, 1986·International Journal of Radiation Oncology, Biology, Physics·D J ChaplinP L Olive

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Citations

Mar 5, 2009·Apoptosis : an International Journal on Programmed Cell Death·Da-Yong YuTakashi Kondo
Aug 6, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Y ShibamotoM Tsujitani
Feb 1, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J Michael HenkStephen F Shepherd
Oct 6, 1997·International Journal of Radiation Oncology, Biology, Physics·F EschwègeC Hill
Jan 6, 2001·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·S MurugesanL Kothari
Dec 13, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Werner DobrowskyHideo Tatsuzaki
Apr 23, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jens Overgaard
Sep 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jens Overgaard
Jun 6, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huafan HuangTaiwei Chu
Jan 6, 2006·Journal of Radiation Research·Chikao SugieHitoshi Hori

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