An Overview of the Pathophysiology of Metabolic Changes and Their Sequence of Occurrence in Obese Diabetic Females: A Narrative Review

Curēus
Azeezat A OyewandeSafeera Khan

Abstract

Obesity and diabetes both mediate their effects through insulin resistance and frequently co-exist. Insulin resistance is one of the key factors in the development of the metabolic syndrome. Adult females tend to develop obesity more frequently than males. One of the factors causing this difference is the pattern of changes that occur as females age from pre-menopausal to the post-menopausal stage, causing a change in the pattern of accumulation of fats. Several studies have explored and described the association between obesity and metabolic syndrome and their effect on type II diabetes. We conducted our literature search using PubMed and Google Scholar as our primary databases. We selected a total of 49 articles for review after applying the inclusion and exclusion criteria and removing the duplicate articles. We chose the full-text articles that were published in the English language only. The selected studies were randomized controlled trials and review papers. The reviewed articles showed that visceral fat, central obesity, and fasting blood sugar of post-menopausal is higher than in pre-menopausal women and needs adequate management. More studies are needed in the future to explore the patterns of the metabolic changes in...Continue Reading

References

Aug 23, 2000·The Journal of Clinical Investigation·B B Kahn, J S Flier
Jan 16, 2002·JAMA : the Journal of the American Medical Association·Earl S FordWilliam H Dietz
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A Astrup, N Finer
Aug 29, 2002·Gastroenterology·Samuel KleinHarvey J Sugerman
Nov 25, 2005·Diabetes·Mikael KnipHans K Akerblom
Mar 15, 2006·Journal of Hypertension·Panteleimon A Sarafidis, Peter M Nilsson
May 15, 2007·Current Opinion in Lipidology·Cristina Lara-CastroW Timothy Garvey
Jul 27, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gianfranco ParatiKrzysztof Narkiewicz
Sep 30, 2008·Tropical Doctor·Kolawole Wasiu WahabMahmoud Yandutse
Oct 31, 2008·Endocrine Reviews·Marc-Andre CornierRobert H Eckel
Jun 6, 2009·Irish Journal of Medical Science·F AlSarajS Sreenan
Dec 22, 2009·Nutrition·Undurti N Das
Feb 26, 2010·Diabetology & Metabolic Syndrome·Anthonia O Ogbera
Feb 22, 2011·International Journal of Epidemiology·Emilie AgardhAnna Sidorchuk
Mar 8, 2012·Menopause : the Journal of the North American Menopause Society·Joseph AbdulnourDenis Prud'homme
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Nov 20, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S O'Neill, L O'Driscoll
Dec 24, 2014·Acta Physiologica Hungarica·G MarićNela Puškaš
Oct 7, 2015·Frontiers in Endocrinology·Xiaoyong Yang, Hai-Bin Ruan
Dec 23, 2016·Diabetes Research and Clinical Practice·Julia H GoedeckeAndre Pascal Kengne
Oct 7, 2017·Mayo Clinic Proceedings·Ekta KapoorStephanie S Faubion
Oct 27, 2017·Pediatric endocrinology, diabetes, and metabolism·Zygmunt ZdrojewiczBartłomiej Śmieszniak

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