An overview of the phytoestrogen effect on vaginal health and dyspareunia in peri- and post-menopausal women

Post Reproductive Health
Fatemeh Rajab DizavandiSareh Dashti

Abstract

The aim of this overview was to evaluate the effectiveness of phytoestrogens on vaginal health and dyspareunia in peri- and post-menopausal women. Three databases including MEDLINE, Scopus and the Cochrane Central Register of Controlled Trials were from inception to August 2017. Two systematic reviews and 11 RCTs were included in the overview. According to the findings, isoflavones increased the maturation value and attenuated the vaginal atrophy in the post-menopausal women. Topical isoflavones had beneficial effects on the vaginal atrophy. Similar efficacy was found in Pueraria mirifica and conjugated estrogen cream on dryness ( p = 0.277), soreness ( p = 0.124) and irritation ( p = 0.469), as well as discharge ( p = 0.225) and dyspareunia ( p = 0.089). However, the conjugated estrogen cream was more effective compared to Pueraria mirifica ( p > 0.005) regarding maturation index improvement. Comparison of fennel 5% vaginal cream and placebo gel showed significant difference in superficial cells ( p < 0.01), parabasal cells ( p < 0.01) and intermediate cells ( p < 0.01), whereas no difference was found between the oral fennel and placebo in terms of superficial, parabasal and intermediate cells as well as Maturation value. Adm...Continue Reading

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Aug 31, 2019·Medicina·Pasquale De FranciscisAntonio Schiattarella
Mar 25, 2021·Gynécologie, Obstétrique, Fertilité & Sénologie·C HockéM Grellety-Cherbero
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Jun 12, 2021·Revista española de geriatría y gerontología·Cristina Chávez-PérezAbel Suárez-Castro

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