An Overview of the Potential Therapeutic Applications of CO-Releasing Molecules

Bioinorganic Chemistry and Applications
Aiten IsmailovaIan S Butler

Abstract

Carbon monoxide (CO) has long been known as the "silent killer" owing to its ability to form carboxyhemoglobin-the main cause of CO poisoning in humans. Its role as an endogenous neurotransmitter, however, was suggested in the early 1990s. Since then, the biological activity of CO has been widely examined via both the direct administration of CO and in the form of so-called "carbon monoxide releasing molecules (CORMs)." This overview will explore the general physiological effects and potential therapeutic applications of CO when delivered in the form of CORMs.

References

Jan 1, 1975·Annual Review of Pharmacology·R D Stewart
Dec 1, 1967·Annals of Internal Medicine·R F AndersonW J DeGroot
Jan 15, 1993·Science·A VermaS H Snyder
Sep 19, 1997·Experimental Neurology·C A PiantadosiD E Schmechel
Mar 26, 1998·Experimental Neurology·H M SchipperE G Stopa
Oct 26, 1999·European Neurology·I S Choi, H Y Cheon
Dec 22, 1999·Journal of Cognitive Neuroscience·K HenkeM S Gazzaniga
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·L XueJ H Szurszewski
Jun 19, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·J T ChapmanA M Choi
Feb 9, 2002·Circulation Research·Roberto MotterliniColin J Green
Jul 5, 2003·Circulation Research·James E ClarkRoberto Motterlini
May 15, 2004·American Journal of Respiratory and Critical Care Medicine·Tamás DolinayAugustine M K Choi
Nov 24, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Roberto MotterliniColin J Green
Nov 18, 2005·American Journal of Physiology. Renal Physiology·Yasin TayemRoberto Motterlini
Mar 29, 2006·Clinics in Laboratory Medicine·Louise W Kao, Kristine A Nañagas
May 13, 2006·American Journal of Respiratory and Critical Care Medicine·Raphaël FavoryRémi Nevière
Jun 15, 2006·The Journal of Pharmacology and Experimental Therapeutics·Mohamed G Bani-HaniRoberto Motterlini
Nov 21, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Muntaser D MusamehRoberto Motterlini
Jan 22, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jean A NemzekOmorodola Abatan
Feb 21, 2008·Intensive Care Medicine·Roberta ForestiRoberto Motterlini
Apr 2, 2008·Chemical Communications : Chem Comm·Johanna NieselUlrich Schatzschneider
Aug 30, 2008·International Journal of Biological Sciences·Bingwei SunGengsheng Shi
Nov 4, 2008·The British Journal of Ophthalmology·E StagniF Drago
May 7, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G NielsenJames F George
Dec 19, 2009·American Journal of Respiratory and Critical Care Medicine·Lucas AndreSylvain Richard
Aug 24, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Leah A MitchellJacob D McDonald
Dec 7, 2010·Journal of the American Chemical Society·Urara HasegawaJeffrey A Hubbell
Feb 8, 2011·Pharmacology & Therapeutics·Claudio Bucolo, Filippo Drago
Feb 26, 2011·Angewandte Chemie·Steffen RomanskiHans-Günther Schmalz
Jul 7, 2011·Current Medicinal Chemistry·T Santos-SilvaM J Romão
Aug 26, 2011·Antioxidants & Redox Signaling·Mathieu DesmardRoberto Motterlini
Oct 20, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G NielsenKeith Vosseller
Dec 14, 2011·Antimicrobial Agents and Chemotherapy·Ana C PenaAna Pamplona
Jan 25, 2012·Basic & Clinical Pharmacology & Toxicology·Ian C WinburnJoanne C Harrison
Feb 22, 2012·Chemical Society Reviews·Carlos C RomãoGonçalo J L Bernardes
Jun 26, 2012·Basic & Clinical Pharmacology & Toxicology·Elisabeth LangFlorian Lang
Jul 10, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Karol KramkowskiWlodzimierz Buczko

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Citations

Sep 24, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Kanika JainJohn Hwa
Oct 1, 2020·Molecular Medicine·Maurizio Dattilo
Mar 14, 2021·Pharmacological Reports : PR·Artur PałaszJohn J Worthington
Aug 7, 2021·Frontiers in Pharmacology·Wout VerbeurePeter R van Dijk
Oct 31, 2020·Chemical Reviews·Roy WeinstainPetr Klán
Jan 27, 2022·Journal of the American Chemical Society·Linfeng XingYoujun Yang

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Methods Mentioned

BETA
nuclear translocation
IECs

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