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An overview on chemical structures as ΔF508-CFTR correctors

European Journal of Medicinal Chemistry

Oct 15, 2019

Virginia SpanòPaola Barraja

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Abstract

Deletion of phenylalanine at position 508 (F508del) in the CFTR protein, is the most common mutation causing cystic fibrosis (CF). F508del causes misfolding and rapid degradation of CFTR protein a defect that can be targeted with pharmacological agents termed "correctors". Correctors be...read more

Mentioned in this Paper

Cystic Fibrosis
Gene Deletion
Nitrogen
Phenylalanine
Protein Folding
Chemicals
Mutant
Oxygenous heterocyclic compound
Structure
Positioning Attribute
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An overview on chemical structures as ΔF508-CFTR correctors

European Journal of Medicinal Chemistry

Oct 15, 2019

Virginia SpanòPaola Barraja

PMID: 31326599

DOI: 10.1016/j.ejmech.2019.07.037

Abstract

Deletion of phenylalanine at position 508 (F508del) in the CFTR protein, is the most common mutation causing cystic fibrosis (CF). F508del causes misfolding and rapid degradation of CFTR protein a defect that can be targeted with pharmacological agents termed "correctors". Correctors be...read more

Mentioned in this Paper

Cystic Fibrosis
Gene Deletion
Nitrogen
Phenylalanine
Protein Folding

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