An overview on recent in vivo biological application of cerium oxide nanoparticles

Asian Journal of Pharmaceutical Sciences
Baskaran Stephen Inbaraj, Bing-Huei Chen

Abstract

Cerium oxide nanoparticles (CNPs) possess a great potential as therapeutic agents due to their ability to self-regenerate by reversibly switching between two valences +3 and +4. This article reviews recent articles dealing with in vivo studies of CNPs towards Alzheimer's disease, obesity, liver inflammation, cancer, sepsis, amyotrophic lateral sclerosis, acute kidney injury, radiation-induced tissue damage, hepatic ischemia reperfusion injury, retinal diseases and constipation. In vivo anti-cancer studies revealed the effectiveness of CNPs to reduce tumor growth and angiogenesis in melanoma, ovarian, breast and retinoblastoma cancer cell-induced mice, with their conjugation with folic acid, doxorubicin, CPM, or CXC receptor-4 antagonist ligand eliciting higher efficiency. After conjugation with triphenylphosphonium or magnetite nanoparticles, CNPs were shown to combat Alzheimer's disease by reducing amyloid-β, glial fibrillary acidic protein, inflammatory and oxidative stress markers in mice. By improving muscle function and longevity, the citrate/EDTA-stabilized CNPs could ameliorate amyotrophic lateral sclerosis. Also, they could effectively reduce obesity in mice by scavenging ROS and reducing adipogenesis, triglyceride synt...Continue Reading

Citations

Jan 29, 2021·Frontiers in Molecular Biosciences·Adityanarayan MohapatraIn-Kyu Park
May 26, 2021·ACS Applied Materials & Interfaces·Raoul WaltherAlexander N Zelikin
Jun 18, 2021·Beilstein Journal of Nanotechnology·Robert A YokelEric A Grulke

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Precipitation
transgenic
xenograft
xenografts
biopsies

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