PMID: 26350336Sep 10, 2015Paper

An Overview on the Search for Schizophrenia Biomarkers

CNS & Neurological Disorders Drug Targets
Jaime Eduardo Cecilio HallakJoao Paulo Machado-de-Sousa

Abstract

Schizophrenia is a severe psychiatric disorder with a complex presentation comprising positive symptoms (e.g.: hallucinations and delusions), negative symptoms (e.g.: social withdrawal, blunted affect) and pervasive cognitive deficits that have been associated with functional decline. The pathophysiology of the disorder is equally complex, with abnormalities known to occur in the molecular, cellular, neurophysiological, and neuroanatomical domains. Despite significant progress in the comprehension of the various manifestations of schizophrenia, the full picture of its etiology remains unknown. As a result, currently available pharmacological treatments have limited efficacy and little has improved since the discovery of the first antipsychotics back in the 1950s. In addition, these medications have significant adverse effects. Differently from other medical areas, the diagnosis of schizophrenia is essentially clinical and dependent on subjective elements. In an attempt to change this, efforts have been directed to find biomarkers of the disorder that could improve diagnostic accuracy and validity, predict treatment response, enable the early identification of individuals at risk of developing schizophrenia and indicate new targ...Continue Reading

Citations

Mar 28, 2019·CNS Spectrums·Erik Pommerening DornellesSílvia Ouakinin
May 20, 2020·Frontiers in Psychiatry·Danielle Gouvêa-JunqueiraFernanda Crunfli

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