An Ovine Model of Hyperdynamic Endotoxemia and Vital Organ Metabolism.

Shock
Liam ByrneJohn F Fraser

Abstract

Animal models of endotoxemia are frequently used to understand the pathophysiology of sepsis and test new therapies. However, important differences exist between commonly used experimental models of endotoxemia and clinical sepsis. Animal models of endotoxemia frequently produce hypodynamic shock in contrast to clinical hyperdynamic shock. This difference may exaggerate the importance of hypoperfusion as a causative factor in organ dysfunction. This study sought to develop an ovine model of hyperdynamic endotoxemia and assess if there is evidence of impaired oxidative metabolism in the vital organs. Eight sheep had microdialysis catheters implanted into the brain, heart, liver, kidney, and arterial circulation. Shock was induced with a 4 h escalating dose infusion of endotoxin. After 3 h vasopressor support was initiated with noradrenaline and vasopressin. Animals were monitored for 12 h after endotoxemia. Blood samples were recovered for hemoglobin, white blood cell count, creatinine, and proinflammatory cytokines (IL-1Beta, IL-6, and IL-8). The endotoxin infusion was successful in producing distributive shock with the mean arterial pressure decreasing from 84.5 ± 12.8 mm Hg to 49 ± 8.03 mm Hg (P < 0.001). Cardiac index remain...Continue Reading

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Citations

Jun 9, 2018·American Journal of Respiratory and Critical Care Medicine·Liam ByrneJohn F Fraser
Nov 24, 2018·Respiratory Research·Margaret R PassmoreJohn F Fraser
Dec 19, 2017·Shock·Marcin F Osuchowski
Feb 8, 2019·Frontiers in Pediatrics·Nchafatso Gikenyi ObonyoJohn Francis Fraser
Apr 21, 2020·Journal of Dairy Science·D NaylorN A Karrow

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