An oviposition-inducing peptide: isolation, localization, and function of avian galanin in the quail oviduct

Endocrinology
D LiK Nomoto

Abstract

It is well established that avian oviposition is regulated, at least partly, by a neurohypophysial hormone, arginine vasotocin, and ovarian hormones, prostaglandins, are regulated through mechanisms of the induction of uterine contractions. Although abundant nerves are terminated in the musculature in the uterine and vaginal oviduct regions, limited information is available on the neuronal control mechanism of avian oviposition. To identify the oviduct factor that plays an important role in the induction of oviposition as a neurotransmitter or a neuromodulator, a study was conducted to isolate the bioactive substance involved in the vaginal and uterine contractions from mature oviducts of the Japanese quail. Acetic acid extracts of 200 quail oviducts were forced through disposable C-18 reversed-phase cartridges, and then the retained material was subjected to the reversed-phase and cation-exchange HPLC purifications. A purified bioactive substance showed a single peak on the reversed-phase HPLC and was further subjected to amino acid sequence analysis and molecular weight presumption. The substance was identified as avian galanin, which was previously isolated from chicken intestine. The synthetic peptide enhanced contractions ...Continue Reading

Citations

Feb 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Takayoshi UbukaKazuyoshi Tsutsui
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Oct 6, 2021·Neuroendocrinology·Takayoshi Ubuka, Kazuyoshi Ukena

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