Abstract
The aim of this study was to confirm the efficacy of patient-driven titration of BIAsp 30 in terms of glycemic control, by comparing it to physician-driven titration of BIAsp 30, in patients with type 2 diabetes in North Africa, the Middle East, and Asia. A 20-week, open-label, randomized, two-armed, parallel-group, multicenter study in Egypt, Indonesia, Morocco, Saudi Arabia, and Vietnam. Patients (n = 155) with type 2 diabetes inadequately controlled using neutral protamine Hagedorn (NPH) insulin were randomized to either patient-driven or physician-driven BIAsp 30 titration. The noninferiority of patient-driven compared to physician-driven titration with respect to the reduction in HbA1c was confirmed. The estimated mean change in HbA1c from baseline to week 20 was -1.27% in the patient-driven arm and -1.04% in the physician-driven arm, with an estimated treatment difference of -0.23% (95% confidence interval: -0.54; 0.08). After 20 weeks of treatment, the proportions of patients achieving the target of HbA1c <7.5% were similar between titration arms; the proportions of patients achieving the target of ≤6.5% were also similar. Both titration algorithms were well tolerated, and hypoglycemic episode rates were similar in both ...Continue Reading
References
Oct 7, 1997·Diabetes Care·C WeyerL Heinemann
Apr 28, 2005·Diabetes Care·UNKNOWN Workgroup on Hypoglycemia, American Diabetes Association
May 28, 2005·Diabetes Care·Melanie DaviesUNKNOWN ATLANTUS Study Group
Oct 4, 2005·Clinical Therapeutics·Arturo R Rolla, Robert E Rakel
Oct 11, 2007·Diabetes, Obesity & Metabolism·L MeneghiniJ-L Selam
Jun 27, 2008·The American Journal of Medicine·Arturo Rolla
Sep 20, 2008·Clinical Medicine & Research·Israel Hartman
Mar 17, 2009·Primary Care Diabetes·Robert J Ligthelm
Jun 9, 2009·International Journal of Clinical Practice·J GumprechtUNKNOWN IMPROVE Study Group Expert Panel
Sep 11, 2009·Health and Quality of Life Outcomes·Meryl BrodDonald M Bushnell
Oct 27, 2009·The American Journal of Medicine·David S OyerUNKNOWN INITIATEplus Study Group
Dec 24, 2010·Diabetes Technology & Therapeutics·UNKNOWN ATLAS Study Group
Apr 25, 2012·Diabetes Technology & Therapeutics·Melba A Hernandez-TejadaLeonard E Egede
Dec 21, 2012·Diabetes, Obesity & Metabolism·K KhuntiS Kalra
Dec 5, 2013·Globalization and Health·Pradana SoewondoDicky Levenus Tahapary
Jan 30, 2014·International Journal of Clinical Practice·M A AlmaatouqS Zatari
Sep 3, 2014·Current Medical Research and Opinion·Yan GaoBanshi Saboo
Sep 25, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·A ZafarK Khunti
Oct 10, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Satish K GargRiccardo Perfetti
Dec 9, 2014·Diabetes & Metabolism·R MalekE Van den Berg
Dec 30, 2014·Diabetes Care·Silvio E InzucchiDavid R Matthews
Jun 30, 2015·Diabetes Research and Clinical Practice· Idf Diabetes Atlas Group
Aug 19, 2015·Endocrine·Dario GiuglianoKatherine Esposito
Dec 24, 2015·Diabetes Care
Jan 9, 2016·Diabetes, Obesity & Metabolism·K KhuntiS K Paul
Jan 28, 2016·Journal of Diabetes Investigation·Wenying YangGangyi Yang
Nov 1, 2014·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·M YongF Yunyun
Jun 14, 2016·Therapeutic Advances in Endocrinology and Metabolism·Asmae ChadliGhizlaine Belmejdoub