PMID: 7545073May 1, 1994Paper

An RNA pocket for an aliphatic hydrophobe

Nature Structural Biology
I Majerfeld, M Yarus

Abstract

We have isolated an RNA with specific affinity for the L-valine side chain, using selection-amplification. The active RNA secondary structure, identified by repeated selection, is a highly conserved asymmetric (4:10) internal loop adjacent to required G-U pairs. The binding free-energy per methylene is up to 1.5 kcal mol-1, and very dependent on group position. Amino acid binding is L-stereoselective and distinguishes aliphatic sidechains by size and, given the same total size, by configuration. Though aliphatic-RNA interactions have frequently been neglected, their avidity and specificity seem sufficient for a biological role.

References

Jan 1, 1990·Methods in Enzymology·J A JaegerM Zuker
Aug 30, 1990·Nature·A D Ellington, J W Szostak
Jan 1, 1981·Journal of Molecular Evolution·A L Weber, S L Miller
Oct 7, 1993·Nature·Y KimP B Sigler
Jun 1, 1993·Biochemistry·G J ConnellM Yarus

❮ Previous
Next ❯

Citations

Oct 8, 1997·Journal of Molecular Evolution·S Alberti
Jul 7, 2005·Journal of Molecular Evolution·Irene MajerfeldMichael Yarus
Oct 2, 2009·Journal of Molecular Evolution·Michael YarusRob Knight
Jan 1, 1997·Progress in Biophysics and Molecular Biology·M G Wallis, R Schroeder
Feb 1, 1997·Trends in Biochemical Sciences·M IbbaD Söll
Jun 1, 1997·Bioorganic & Medicinal Chemistry·B A GilbertR R Rando
Sep 30, 1998·Chemistry & Biology·R D Knight, L F Landweber
May 1, 1994·Nature Structural Biology
Aug 1, 1997·Nature Structural Biology·H A Heus
Feb 22, 2005·Nature Structural & Molecular Biology·Alexander SerganovDinshaw J Patel
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·L Chen, A D Frankel
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·J A DoudnaB A Sullenger
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·S RodinS Ohno
Apr 4, 2001·The EMBO Journal·H SaitoH Suga
Oct 28, 1999·Nucleic Acids Research·V BourdeauR Cedergren
May 10, 2002·Nucleic Acids Research·Krishna RamaswamyHiroaki Suga
Feb 3, 1995·Science·M IllangasekareM Yarus
Jan 1, 1997·Annual Review of Biochemistry·G J Narlikar, D Herschlag
Jun 29, 2000·Annual Review of Biochemistry·D S Wilson, J W Szostak
Nov 15, 2012·Journal of Nucleic Acids·Maureen McKeague, Maria C Derosa
Oct 17, 2003·RNA·Catherine LozuponeMichael Yarus
Feb 8, 2014·Analytical Chemistry·Sonia Amaya-GonzálezM Jesús Lobo-Castañón
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·A KhvorovaM Yarus
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·L F Landweber
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·F Huang, M Yarus
May 8, 2015·Journal of Drug Targeting·A GanjiM Sankian
Jul 14, 2007·Biomolecular Engineering·Regina StoltenburgBeate Strehlitz
Jul 24, 2013·Journal of Molecular Evolution·Harry BuhrmanLeen Stougie
Nov 24, 2004·Current Opinion in Chemical Biology·Randall A HughesMatthew Levy
May 1, 1994·Current Biology : CB·A D Ellington
Jun 30, 2010·Cellular & Molecular Biology Letters·Teresa Janas, Tadeusz Janas
Nov 14, 2002·Annual Review of Genetics·Michael Yarus
Jun 11, 1999·Current Opinion in Structural Biology·M Famulok
Sep 1, 1995·Current Biology : CB·I Hirao, A D Ellington
Oct 1, 1995·Chemistry & Biology·B E EatonD A Zichi
Oct 23, 1997·Chemistry & Biology·T W WiegandB E Eaton
Sep 1, 1996·Chemistry & Biology·A J HagerJ W Szostak
Mar 24, 2017·Life·Michael Yarus
Feb 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cao-An Vu, Wen-Yih Chen
Nov 16, 2010·The Analyst·Xiaojuan YangDihua Shangguan
Mar 18, 2005·The Journal of Biological Chemistry·Michal Legiewicz, Michael Yarus
Jul 4, 2020·Applied Microbiology and Biotechnology·Jennifer TullmanZvi Kelman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.