An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice

The EMBO Journal
P D AplanK W Gross

Abstract

The product of the scl (also called tal-1 or TCL5) gene is a basic domain, helix-loop-helix (bHLH) transcription factor required for the development of hematopoietic cells. Additionally, scl gene disruption and dysregulation, by either chromosomal translocations or a site-specific interstitial deletion whereby 5' regulatory elements of the sil gene become juxtaposed to the body of the scl gene, is associated with T-cell acute lymphoblastic leukemia (ALL) and T-cell lymphoblastic lymphoma. Here we show that an inappropriately expressed scl protein, driven by sil regulatory elements, can cause aggressive T-cell malignancies in collaboration with a misexpressed LMO1 protein, thus recapitulating the situation seen in a subset of human T-cell ALL. Moreover, we show that inappropriately expressed scl can interfere with the development of other tissues derived from mesoderm. Lastly, we show that an scl construct lacking the scl transactivation domain collaborates with misexpressed LMO1, demonstrating that the scl transactivation domain is dispensable for oncogenesis, and supporting the hypothesis that the scl gene product exerts its oncogenic action through a dominant-negative mechanism.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Oct 1, 1992·The Journal of Experimental Medicine·O BernardD Mathieu-Mahul
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T BoehmT H Rabbitts
Dec 1, 1990·Molecular and Cellular Biology·P D AplanI R Kirsch
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C G BegleyI R Kirsch
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L R FingerC M Croce
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·L RobbC G Begley
Nov 10, 1994·Nature·T H Rabbitts
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·H L HsuR Baer
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·A F Voronova, F Lee
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·I Sánchez-García, T H Rabbitts
Jan 1, 1994·Leukemia & Lymphoma·A N Goldfarb, J M Greenberg
Feb 1, 1994·Molecular and Cellular Biology·H L HsuR Baer
Feb 2, 1996·The Journal of Biological Chemistry·A N GoldfarbM Shoham
Dec 10, 1995·Genomics·N Collazo-GarciaP D Aplan
Oct 17, 1996·Nature·T Green

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Citations

Sep 3, 2008·Science in China. Series C, Life Sciences·T ZhuB Royer-Pokora
Aug 14, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Di WangLiang Huang
Dec 4, 2003·Biochemical and Biophysical Research Communications·Anders HanssonHåkan Axelson
Jan 17, 2004·Experimental Hematology·Eric Lécuyer, Trang Hoang
Jan 18, 2003·Biochimica Et Biophysica Acta·Tina Colaizzo-Anas, Peter D Aplan
Dec 6, 1997·Current Opinion in Genetics & Development·M A Cross, T Enver
Dec 3, 1999·The International Journal of Biochemistry & Cell Biology·L M BartonA R Green
Apr 12, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Pedro J RealPablo Menendez
Jul 22, 2005·Nature Reviews. Cancer·Jonathan PerkRobert Benezra
Apr 19, 2008·Nature Reviews. Immunology·Iannis AifantisSilvia Buonamici
Sep 2, 1998·The EMBO Journal·S Cohen-KaminskyP H Roméo
Jun 3, 2010·Genes & Development·Mathieu TremblayTrang Hoang
Jan 11, 2002·Molecular and Cellular Biology·Sabine HerblotTrang Hoang
Aug 18, 2004·Molecular and Cellular Biology·Thorsten M SchlaegerCatherine Porcher
Jan 30, 2004·Molecular and Cellular Biology·Rachid LahlilTrang Hoang
Sep 12, 2008·Annual Review of Pathology·Michael A Teitell, Pier Paolo Pandolfi
Oct 2, 2012·The Journal of Clinical Investigation·Pieter Van Vlierberghe, Adolfo Ferrando
Feb 28, 2009·Blood·Kathleen CullionMichelle A Kelliher
Aug 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Elena LevantiniMaria Cristina Magli
Dec 23, 2015·Stem Cells and Development·Ilana Carmel-GrossAchia Urbach
Jun 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Hyung-Ok LeeDietmar J Kappes
Apr 27, 2007·Neoplasia : an International Journal for Oncology Research·Yue ChengPeter D Aplan
Mar 13, 2010·Cancer Treatment Reviews·Jean Pierre Bourquin, Shai Izraeli
Jun 17, 2004·British Journal of Haematology·Shai Izraeli
Feb 16, 2012·Genes, Chromosomes & Cancer·Masahiro Onozawa, Peter D Aplan
Nov 20, 2013·Genes, Chromosomes & Cancer·Marie LoosveldDominique Payet-Bornet
Jul 10, 2013·Blood·Julie LacombeTrang Hoang
May 23, 2014·Frontiers in Oncology·Elad JacobyTerry J Fry
Dec 19, 2014·PLoS Genetics·Bastien GerbyTrang Hoang

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