An S/G2 Checkpoint Regulated by ATR Preserves Genome Integrity

Cancer Discovery

Abstract

Cells possesses an ATR-enforced intrinsic checkpoint controlling the S/G2 transition.

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Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

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