PMID: 18719369Aug 23, 2008Paper

An SNP-guided microRNA map of fifteen common human disorders identifies a consensus disease phenocode aiming at principal components of the nuclear import pathway

Cell Cycle
Gennadi V Glinsky

Abstract

Recent large-scale genome-wide association (GWA) studies of SNP variations captured many thousands individual genetic profiles of H. sapiens and facilitated identification of significant genetic traits which are highly likely to influence the pathogenesis of several major human diseases. Here we apply the integrative genomics principles to interrogate relationships between structural features and gene expression patterns of disease-linked SNPs, microRNAs and mRNAs of protein-coding genes in association to phenotypes of 15 major human disorders, namely bipolar disease (BD); rheumatoid arthritis (RA); coronary artery disease (CAD); Crohn's disease (CD); type 1 diabetes (T1D); type 2 diabetes (T2D); hypertension (HT); ankylosing spondylitis (AS); Graves' disease (autoimmune thyroid disease; AITD); multiple sclerosis (MS); breast cancer (BC); prostate cancer (PC); systemic lupus erythematosus (SLE); vitiligo-associated multiple autoimmune disease (VIT); and ulcerative colitis (UC). We selected for sequence homology profiling a set of approximately 250 SNPs which were unequivocally associated with common human disorders based on multiple independent studies of 220,124 individual samples comprising 85,077 disease cases and 129,506 co...Continue Reading

Citations

May 4, 2010·Analytical and Bioanalytical Chemistry·Bing YangLequn Lee Huang
Nov 28, 2012·Functional & Integrative Genomics·Lei ZhaoTao Xia
Jan 1, 2010·Indian Journal of Clinical Biochemistry : IJCB·G P George, Rama Devi Mittal
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Sep 11, 2012·Thyroid : Official Journal of the American Thyroid Association·Christian BerneckerMatthias Schott
May 12, 2011·Rheumatology·Binbin WangChanggui Li
Nov 4, 2010·Current Opinion in Nephrology and Hypertension·Maple M FungDaniel T O'Connor
Apr 30, 2010·Personalized Medicine·Prasun J Mishra
Dec 29, 2010·Autoimmune Diseases·Kemal Ugur TufekciKursad Genc
Sep 8, 2012·Cellular and Molecular Life Sciences : CMLS·Nicole Schonrock, Jürgen Götz
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Sep 10, 2019·Molecular Genetics & Genomic Medicine·Kang HuangShufang Zhang

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