An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese.

Scientific Reports
Guoliang ZhangJunwen Wang

Abstract

Recent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The SNP shows associations with p-values of 0.028 and 0.034 respectively, and a combined p-value of 0.0086, with odds ratio at 0.65 (95% confidence interval 0.45-0.90). We further validated the association with an independent cohort (413 cases and 241 controls in Chinese). Our functional studies showed that patients with A allele have significantly higher IL-22 expression than those without A allele under both non-specific and specific stimulations.

References

Jun 1, 1990·Genes & Development·M J Evans, R C Scarpulla
Oct 3, 2002·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·D LioC Caruso
Jan 10, 2003·Nucleic Acids Research·V MatysE Wingender
Dec 19, 2003·Nucleic Acids Research·Albin SandelinBoris Lenhard
Mar 25, 2004·American Journal of Respiratory Cell and Molecular Biology·Hayley A WhittingtonAnn B Millar
Aug 6, 2004·The Journal of Infectious Diseases·Hoi W TsoAlan K S Chiang
Aug 17, 2004·Immunity·Kerstin WolkRobert Sabat
Oct 26, 2005·Nature Genetics·Paul I W de BakkerDavid Altshuler
Dec 31, 2005·Nucleic Acids Research·Mark HeigesJessica C Kissinger
Aug 22, 2006·Biochemical and Biophysical Research Communications·Junwen WangHung Tseng
Sep 6, 2006·Circulation·Sridhar HannenhalliThomas P Cappola
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas J ScribaWillem A Hanekom
Feb 12, 2008·Nature Medicine·Shean J AujlaJay K Kolls
Mar 28, 2008·Scandinavian Journal of Immunology·B Rivas-SantiagoR Hernández-Pando
Jun 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Erandi K De SilvaManuel Llinás
Oct 10, 2008·Nucleic Acids Research·Daniel E Newburger, Martha L Bulyk
Oct 30, 2008·Nucleic Acids Research·Cristina AurrecoecheaHaiming Wang
May 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lucia A HindorffTeri A Manolio
Oct 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rohan DhimanRamakrishna Vankayalapati
Dec 19, 2009·American Journal of Respiratory and Critical Care Medicine·Xinchun ChenBoping Zhou
Mar 5, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jae-Joon Yim, Paramasivam Selvaraj

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Citations

Oct 21, 2016·Microbiology and Immunology·Gamal AllamAmre Nasr
May 16, 2017·Nature Microbiology·Bibhuti B MishraChristopher M Sassetti
Nov 28, 2017·Cellular & Molecular Immunology·Hongbo Shen, Zheng W Chen
Nov 13, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shan-Yu QinHai-Xing Jiang
May 7, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark S GresnigtFrank L van de Veerdonk
Aug 6, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cecilia Lindestam ArlehamnBjoern Peters
May 5, 2017·Nucleic Acids Research·Mulin Jun LiX Shirley Liu
Aug 26, 2017·International Journal of Endocrinology·Rong-Hua SongJin-An Zhang
Oct 16, 2018·Frontiers in Immunology·Katharina RonacherMichelle Cestari
Mar 10, 2020·Mediators of Inflammation·Nada H AljarbaAhmed A Al-Qahtani
Aug 15, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rubina BunjunWendy A Burgers

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Methods Mentioned

BETA
genotyping
X-ray
ELISA

Software Mentioned

FastPval
Mass ARRAY AssayDesign
Jaspar
UniPROBE
Haploview
UCSC genome browser
RNAfold
RNAhybrid
PLINK

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