An ultra-compact particle size analyser using a CMOS image sensor and machine learning.

Light, Science & Applications
Rubaiya HussainValerio Pruneri

Abstract

Light scattering is a fundamental property that can be exploited to create essential devices such as particle analysers. The most common particle size analyser relies on measuring the angle-dependent diffracted light from a sample illuminated by a laser beam. Compared to other non-light-based counterparts, such a laser diffraction scheme offers precision, but it does so at the expense of size, complexity and cost. In this paper, we introduce the concept of a new particle size analyser in a collimated beam configuration using a consumer electronic camera and machine learning. The key novelty is a small form factor angular spatial filter that allows for the collection of light scattered by the particles up to predefined discrete angles. The filter is combined with a light-emitting diode and a complementary metal-oxide-semiconductor image sensor array to acquire angularly resolved scattering images. From these images, a machine learning model predicts the volume median diameter of the particles. To validate the proposed device, glass beads with diameters ranging from 13 to 125 µm were measured in suspension at several concentrations. We were able to correct for multiple scattering effects and predict the particle size with mean ab...Continue Reading

References

Jul 12, 2001·Journal of Colloid and Interface Science·Arturo QuirantesJesús Quirantes-Ros
Dec 28, 2006·Pharmaceutical Research·Boris Y ShekunovAlbert H L Chow
May 11, 2010·Analytical Chemistry·Sungkyu SeoAydogan Ozcan
May 29, 2015·Nature·Yann LeCunGeoffrey Hinton
May 17, 2017·Biophysics Reviews·Jörg StetefeldTrushar R Patel
Sep 1, 2018·Light, Science & Applications·Yi-Chen WuAydogan Ozcan

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Methods Mentioned

BETA
light scattering
dynamic light scattering
static light scattering
irradiate
imaging techniques
light diffraction

Software Mentioned

scikit
image
Sovitec
scikit learn
Guyson
Python
DevWare
MATLAB

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