An Ultrahigh-Performance Liquid Chromatography-Time-of-Flight Mass Spectrometry Metabolomic Approach to Studying the Impact of Moderate Red-Wine Consumption on Urinary Metabolome

Journal of Proteome Research
Adelaida Esteban-FernándezM Victoria Moreno-Arribas

Abstract

Moderate red-wine consumption has been widely described to exert several benefits in human health. This is mainly due to its unique content of bioactive polyphenols, which suffer several modifications along their pass through the digestive system, including microbial transformation in the colon and phase-II metabolism, until they are finally excreted in urine and feces. To determine the impact of moderate wine consumption in the overall urinary metabolome of healthy volunteers ( n = 41), samples from a red-wine interventional study (250 mL/day, 28 days) were investigated. Urine (24 h) was collected before and after intervention and analyzed by an untargeted ultrahigh-performance liquid chromatography-time-of-flight mass spectrometry metabolomics approach. 94 compounds linked to wine consumption, including specific wine components (tartaric acid), microbial-derived phenolic metabolites (5-(dihydroxyphenyl)-γ-valerolactones and 4-hydroxyl-5-(phenyl)-valeric acids), and endogenous compounds were identified. Also, some relationships between parallel fecal and urinary metabolomes are discussed.

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Citations

Jul 11, 2019·Molecular Nutrition & Food Research·Pablo Hernández-AlonsoJordi Salas-Salvadó
Mar 14, 2020·Journal of the Science of Food and Agriculture·Irene ZorraquínBegoña Bartolomé
Sep 10, 2020·Nutrients·Irene Zorraquín-PeñaBegoña Bartolomé
Oct 15, 2020·Nutrients·M Victoria Moreno-ArribasMaria José Motilva

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