An Ultrasensitive, Selective, Multiplexed Superbioelectronic Nose That Mimics the Human Sense of Smell

Nano Letters
Jyongsik JangTai Hyun Park

Abstract

Human sensory-mimicking systems, such as electronic brains, tongues, skin, and ears, have been promoted for use in improving social welfare. However, no significant achievements have been made in mimicking the human nose due to the complexity of olfactory sensory neurons. Combinational coding of human olfactory receptors (hORs) is essential for odorant discrimination in mixtures, and the development of hOR-combined multiplexed systems has progressed slowly. Here, we report the first demonstration of an artificial multiplexed superbioelectronic nose (MSB-nose) that mimics the human olfactory sensory system, leading to high-performance odorant discriminatory ability in mixtures. Specifically, portable MSB-noses were constructed using highly uniform graphene micropatterns (GMs) that were conjugated with two different hORs, which were employed as transducers in a liquid-ion gated field-effect transistor (FET). Field-induced signals from the MSB-nose were monitored and provided high sensitivity and selectivity toward target odorants (minimum detectable level: 0.1 fM). More importantly, the potential of the MSB-nose as a tool to encode hOR combinations was demonstrated using principal component analysis.

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Citations

Mar 30, 2016·Biosensors & Bioelectronics·Hyun Seok SongNatalie Artzi
Sep 7, 2016·Biosensors & Bioelectronics·Tomasz WasilewskiWojciech Kamysz
Oct 8, 2016·ACS Applied Materials & Interfaces·Seon Joo ParkJyongsik Jang
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Feb 12, 2019·ACS Applied Materials & Interfaces·Thanihaichelvan MurugathasNatalie O V Plank
Oct 30, 2018·Chemical Reviews·Oh Seok KwonJyongsik Jang

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