An ultrasmall and metabolizable PEGylated NaGdF4:Dy nanoprobe for high-performance T(1)/T(2)-weighted MR and CT multimodal imaging

Nanoscale
Xiaoying JinLehui Lu

Abstract

Lanthanide-based multimodal probes with high sensitivity, simple synthesis strategy, and good biocompatibility promise new applications for clinical diagnosis. However, today's challenge is not only to develop high-performance multimodal probes for more accurate and reliable diagnosis, but also to understand the fate of these probes in vivo. In this context, a novel PEGylated Dy-doped NaGdF4 nanoprobe (PEG-NaGdF4:Dy) was designed and fabricated as a T1/T2-weighted MRI/CT imaging agent. This nanoprobe has a distinct longitudinal relaxivity (r1 = 5.17 mM(-1) s(-1)), relatively high transverse relaxivity (r2 = 10.64 mM(-1) s(-1)), and exhibits strong X-ray attenuation properties (44.70 HU L g(-1)) in vitro. Furthermore, T1/T2-weighted MRI/CT imaging in vivo confirmed that this PEG-NaGdF4:Dy nanoprobe could lead to a significant contrast enhancement effect on liver, spleen and kidney at 24 h post injection. The MTT assay, histological analysis, and biodistribution investigation demonstrated that this multifunctional nanoprobe possessed relatively low cytotoxicity, negligible tissue damage and could be completely excreted out of the body of mice as time prolonged. Therefore, the present PEG-NaGdF4:Dy nanoprobe has the potential for ...Continue Reading

References

Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Luce Vander ElstRobert N Muller
Mar 22, 2008·Journal of the American Chemical Society·Małgorzata NorekJoop A Peters
Apr 15, 2008·Journal of the American Chemical Society·Christophe AlricOlivier Tillement
Jul 3, 2010·Medical Engineering & Physics·K A M KulmalaJ Töyräs
Dec 6, 2012·Chemical Reviews·Hrvoje Lusic, Mark W Grinstaff
Apr 5, 2013·Advanced Materials·Nohyun LeeTaeghwan Hyeon
Mar 13, 2014·Advanced Materials·Chunyan LiuMingyuan Gao
Feb 16, 2012·The Journal of Physical Chemistry Letters·Gautom Kumar DasFrank C J M van Veggel
Mar 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yunlong DengLing Ye

❮ Previous
Next ❯

Citations

May 31, 2017·ACS Applied Materials & Interfaces·Lile DongHongjie Zhang
Apr 11, 2019·Nanoscale·Peter AgboRebecca J Abergel
Dec 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xueru ShanLehui Lu
Jun 14, 2019·Contrast Media & Molecular Imaging·Juan PellicoJason J Davis
May 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yi CaoRenjun Pei
Nov 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaodong LiZhenxin Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.