An ultrastructural and ultrahistochemical study of the placenta of the diabetic woman

The Journal of Pathology
C J Jones, H Fox

Abstract

An ultrastructural and ultrahistochemical study has been made of placentae from seven women, all of whom were established diabetics before the onset of pregnancy. None of these women had suffered from any of the hypertensive complications of pregnancy. Patchy focal syncytiotrophoblastic necrosis was evident and indirect evidence of syncytial damage was seen in the form of marked cytotrophoblastic hyperplasia. The syncytial necrosis appeared to be lysosomally mediated, possibly as a result of altered intracellular pH. Occasional cytotrophoblastic cells also showed degenerative changes. Most of the villous trophoblast was, however, morphologically normal and showed features suggestive of normal or increased synthetic, transfer and excretory activity. Focal thickening of the villous trophoblastic basement membrane was seen and this did not appear to be due to deposition of immune complexes. The endothelial cells of the villous capillaries appeared unduly immature but no evidence was seen of immune complex deposition in these vessels or of diabetic angiopathy. It is concluded that the diabetic's placenta shows a consistent pattern of abnormalities which appear to be a direct result of the diabetic state.

References

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Citations

Dec 1, 1991·Diabetes/metabolism Reviews·C A Labarrere, W P Faulk
Jan 1, 1994·Molecular Aspects of Medicine·G Desoye, E Shafrir
Jan 1, 1991·Electron Microscopy Reviews·C J Jones, H Fox
Feb 1, 1996·Pathology International·B YounesZ Abu Talib
Apr 1, 1984·Annals of the Rheumatic Diseases·C J Jones, M I Jayson
Jan 5, 2011·Cells, Tissues, Organs·Carolyn J P Jones, G Desoye
Apr 1, 2013·Journal of Marriage and the Family·Keera Allendorf
May 14, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Eumenia C C CastroVicente P A Teixeira
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Related Concepts

Acid Phosphatase
Adenosine Triphosphate, Chromium Ammonium Salt
Alkaline Phosphatase
Pseudo Arylsulfatase A
Basement Membrane
Blood Capillaries
Necrosis
Placenta
Pregnancy in Diabetics
Syncytiotrophoblasts

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