An ultrastructural study of articular chondrocalcinosis in cases of knee osteoarthritis

Virchows Archiv. A, Pathological Anatomy and Histopathology
G Boivin, R Lagier

Abstract

A study was made by transmission electron microscopy of tissue specimens (cartilage, meniscus and synovial membrane) taken from 5 knees presenting radiological and anatomical signs of articular chondrocalcinosis and osteoarthritis. It was part of a broader study which included analysis of the same specimens by macroscopy and light microscopy as well as by X-ray diffraction of the mineral deposits. In cartilage and meniscus juxta-cellular calcium pyrophosphate dihydrate (CPPD) crystals of variable sizes were observed in the extracellular organic matrix, independent of the collagen fibrils. They occurred mainly in the superficial and middle zones but could also be seen intermingled with the apatite crystals in the cartilage calcified zone. In synovial membrane most of the CPPD crystals were extracellular but some of them could be seen in cytoplasmic phagocytic vacuoles. These observations are in agreement with those in the literature regarding the ultrastructural picture of chondrocalcinosis and support the thesis that the crystals originate in the cartilage and are phagocytized in the synovial membrane. Although the results of the present study do not provide direct evidence of a relationship between chondrocalcinosis and osteoa...Continue Reading

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Citations

Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·R LagierJ C Gerster
Apr 23, 2011·Der Pathologe·M FuerstW Rüther
Jul 30, 2009·Rheumatology International·Martin FuerstW Rüther
Jun 14, 2014·Zeitschrift für Rheumatologie·M Fuerst
Aug 29, 2009·Arthritis and Rheumatism·M FuerstW Rüther
May 15, 1997·Microscopy Research and Technique·D L GardnerK Oates
Jan 10, 2012·Current Opinion in Rheumatology·Yubo Sun, David R Mauerhan

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