An un-dopamine hypothesis of schizophrenia

Schizophrenia Bulletin
M Alpert, A J FRIEDHOFF

Abstract

The dopamine hypothesis of schizophrenia is examined critically. Although the hypothesis is couched in chemical terms, the evidence is primarily pharmacologic. In addition, neuroleptic mechanisms do not fit a simple hyperdopaminergic formulation, and treatment efficacy points to a general psychotic rather than specific schizophrenic role for dopamine. Most compromising to the hypothesis is the therapeutic action of L-dopa when combined with neuroleptics in chronic schizophrenics. Dopamine appears important but cannot be viewed as a simple pathogen.

Citations

Jun 1, 1992·Biological Psychiatry·M A WolfC L Shriqui
Feb 13, 2001·Psychiatry Research·M AlpertR J Shaw
Mar 1, 1985·Comprehensive Psychiatry·M Alpert
Jul 1, 1988·Psychophysiology·D C Fowles
Oct 31, 2015·Journal of Neurosurgery·Charles B MikellSameer A Sheth
Jan 1, 1985·International Journal of Psychiatry in Medicine·S R Kay, L A Opler

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