An unconditioned bone marrow transplantation in a child with purine nucleoside phosphorylase deficiency and its unique complication

Pediatric Transplantation
Caner AytekinAydan Ikinciogullari

Abstract

Purine nucleoside phosphorylase deficiency is a rare immunodeficiency syndrome characterized by recurrent infections, neurological dysfunction, and autoimmunity. Early diagnosis and hematopoietic stem cell transplantation may reverse the dismal prognosis in PNP deficiency. This report presents a new PNP deficiency case successfully transplanted without a conditioning regimen from an HLA-identical family donor, who developed a complication of disseminated BCG infection.

References

Dec 29, 2000·Pediatric Clinics of North America·M E Elder
Jul 10, 2002·Bone Marrow Transplantation·A IkincioğullariE Babacan
Dec 18, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hamid Jack MoallemSenih Fikrig
Nov 30, 2007·Emerging Infectious Diseases·Ewa Anna BernatowskaAnna Liberek

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Citations

May 25, 2010·Journal of Inherited Metabolic Disease·Cary O Harding, K M Gibson
Aug 7, 2009·European Journal of Pediatrics·Caner AytekinAydan Ikinciogullari
Jul 6, 2014·Transplant Infectious Disease : an Official Journal of the Transplantation Society·R F Abu-ArjaK R Cooke
Dec 2, 2011·Annals of the New York Academy of Sciences·Ozden Sanal, Ilhan Tezcan
Feb 24, 2015·Immunological Reviews·Stéphanie Boisson-DupuisLaurent Abel
Oct 12, 2013·Current Opinion in Allergy and Clinical Immunology·Eyal GrunebaumChaim M Roifman
Nov 11, 2019·Journal of Clinical Immunology·Yael Dinur SchejterIrina Zaidman

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