An undifferentiated carcinoma at Klatskin-position with long-term complete remission after chemotherapy

Oncotarget
Bruno Christian KöhlerChristoph Springfeld

Abstract

Neoplasms anatomically adjacent to the bile duct usually derive from malignantly transformed cholangiocytes forming cholangiocarcinoma (CCA). CCAs are divided in extrahepatic (eCCA) and intrahepatic (iCCA) tumors. Patients with irresectable CCAs are treated with systemic chemotherapy and have an unfavorable prognosis with a median survival of about one year. Here, we report a case of an undifferentiated carcinoma in Klatskin-position with long-term remission after systemic chemotherapy. A 65-year-old Caucasian male presented with painless jaundice caused by an undifferentiated carcinoma in Klatskin-position (Type IIIb). Alpha fetoprotein (AFP; 3675 IU/mL) and carbohydrate antigen 19-9 (CA 19-9; 183 U/ml) were elevated. An exploratory laparotomy was carried out, but the patient was found to be irresectable due to severe fibrosis caused by biliary obstruction. Histology showed an undifferentiated carcinoma with high proliferation rate, and the patient was therefore subjected to poly-chemotherapy treatment according to the FOLFOX6-protocol. During therapy, AFP decreased to normal. Subsequent CT scans and ERC revealed a complete remission. Four years past initial diagnosis, a new suspicious lesion in the liver is visible on MRT; ho...Continue Reading

References

Sep 8, 1998·Japanese Journal of Clinical Oncology·H NakasukaM Sakamoto
Feb 5, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F Maindrault-GoebelA de Gramont
Jun 29, 2004·Journal of Clinical Gastroenterology·Rungsun RerknimitrPinit Kullavanijaya
Jul 16, 2005·Surgical Oncology·D SinghalD J Gouma
Apr 9, 2010·The New England Journal of Medicine·Juan ValleUNKNOWN ABC-02 Trial Investigators
Dec 18, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·J R IzbickiM Bockhorn
Nov 21, 2013·Surgery Today·Shunji EndoJunichi Nishijima
Jan 11, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jau-Yu LiauYung-Ming Jeng
Jan 12, 2017·Surgical Case Reports·Takashi MaedaHiroyuki Matsuda
May 10, 2017·Journal of Gastrointestinal Oncology·Selley Sahu, Weijing Sun
Jun 5, 2017·Surgical Oncology·Hanisah GuroHo-Seong Han
Sep 16, 2017·International Journal of Surgery Case Reports·Tsuyoshi AbeYasushi Teranishi
Sep 25, 2017·Oncotarget·Bruno Christian KöhlerChristoph Springfeld

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Citations

Jan 18, 2022·Surgical Case Reports·Masayuki AkitaKunihiko Kaneda

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Methods Mentioned

BETA
biopsy

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