PMID: 140145Apr 7, 1977Paper

An unexpected high frequency of trisomic fetuses in 229 pregnancies monitored for advanced maternal age

Human Genetics
E S SachsH Galjaard

Abstract

In 229 pregnancies monitored because of advance maternal age, 16 (7%) abnormal fetal karyotypes were detected. We found 13 cases of trisomy 21, twice a trisomy 18, and once an additional marker chromosome. The frequency of abnormal fetal karyotypes in different maternal age groups was found to increase from 1:20 at 38--40 years, to 1:16 at 41--43 years, and finally to 1:4.5 in women of 44--46 years. The overall incidence of chromosomal aberrations and specifically of trisomy 21 is considerably higher than that described in retrospective studies.

References

Jun 1, 1976·Journal of Medical Genetics·M F NiermeijerH Galjaard
Jan 1, 1976·Advances in Pathobiology·K Hirschhorn
Feb 10, 1973·Lancet·Z SteinA V Guterman
Jul 1, 1974·Acta paediatrica Scandinavica·A Lindsjö
May 1, 1962·American Journal of Public Health and the Nation's Health·R D COLLMANN, A STOLLER

Citations

Apr 30, 2004·Reproductive Biology and Endocrinology : RB&E·A BukovskýNirmala B Upadhyaya
Jan 1, 1978·American Journal of Medical Genetics·L Y HsuK Hirschhorn

Related Concepts

Chromosomes, Human,16-18
Trisomy 21, Mitotic Nondisjunction
Maternal Age
Partial Trisomy

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