An Unexpected Role for TRPV4 in Serotonin-Mediated Itch

The Journal of Investigative Dermatology
Lindsey M SnyderSarah E Ross

Abstract

Previous studies have revealed that TRPV1 and TRPA1 function downstream of many itch receptors, where they mediate inward current to trigger action potentials in primary afferents. Although other TRP channels, such as TRPV4, are expressed in primary afferents, whether or not they play an analogous role in itch was previously unknown. Now, Akiyama et al. provide evidence that TRPV4 is a key mediator of serotonin-induced itch. This finding is important because it uncovers an unanticipated role for TRPV4 in itch, thereby identifying a novel therapeutic target.

References

Aug 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Carlene MooreWolfgang B Liedtke
May 2, 2015·Clinical Reviews in Allergy & Immunology·Nicholas K MollanazarGil Yosipovitch
Jun 16, 2015·Neuron·Takeshi MoritaDiana M Bautista

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Citations

Sep 9, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Babina Sanjel, Won-Sik Shim
Apr 2, 2021·Frontiers in Medicine·Jacqueline A G M LangedijkRonald P J Oude Elferink
Oct 14, 2021·Acta Dermato-venereologica·Dominika Kwiatkowska, Adam Reich

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