An unexpected twist in alopecia areata pathogenesis: are NK cells protective and CD49b+ T cells pathogenic?

Experimental Dermatology
Gil KaufmanAmos Gilhar

Abstract

Natural killer (NK) cells have become a recent focus of interest in alopecia areata (AA) research. To further investigate their role in an established mouse model of AA, lesional skin from older C3H/HeJ mice with AA was grafted to young C3H/HeJ female mice, and NK cells were depleted by continuous administration of rabbit anti-asialo GM1. As expected, this significantly reduced the number of pure NK cells in murine skin, as assessed by NKp46 quantitative immunohistochemistry. Quite unexpectedly, however, the onset of hair loss in C3H/HeJ mice was accelerated, rather than retarded. NK cell depletion was accompanied by a significant increase in the number of perifollicular CD49b+T cells in the alopecic skin of anti-asialo GM1-treated mice. These findings underscore the need to carefully distinguish in future AA research between pure NK cells and defined subsets of CD49b+ lymphocytes, as they may exert diametrically opposed functions in hair follicle immunology and immunopathology.

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Citations

Sep 17, 2013·Journal of Dermatological Science·Sachiko OnoKenji Kabashima
Dec 7, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ivana Bozic AnticSvetozar Damjanovic
Oct 15, 2010·Journal of Dermatological Science·Taisuke Ito
Jun 21, 2016·EBioMedicine·Ali JabbariAngela M Christiano
Oct 2, 2019·Experimental Dermatology·Hoon KangKevin J McElwee
Jul 19, 2020·Experimental Dermatology·Marta BertoliniRalf Paus
Jun 2, 2017·Experimental and Therapeutic Medicine·Guangchuan WangFengping Shan
Oct 14, 2019·The Journal of Allergy and Clinical Immunology·Amos GilharRalf Paus
Aug 1, 2019·Annals of Dermatology·Jong Hyuk MoonGwang Seong Choi
Oct 26, 2020·The Journal of Investigative Dermatology. Symposium Proceedings·Amos GilharRalf Paus
Oct 26, 2020·The Journal of Investigative Dermatology. Symposium Proceedings·Ralf Paus

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