An Unexpectedly High Rate of Thrombophilia Disorders in Patients with Superficial Vein Thrombosis of the Lower Extremities

Annals of Vascular Surgery
Marcone Lima SobreiraWinston Bonetti Yoshida

Abstract

Superficial vein thrombosis (SVT) is a common venous condition. Recent studies have shown that SVT is associated with high frequency of thromboembolic complications: from 22-37% for deep venous thrombosis and up to 33% for pulmonary embolism. Our goal was to assess the prevalence of major hereditary and acquired thrombophilic factors in patients with SVT. Sixty-six patients presenting with primary SVT underwent evaluation for thrombophilia: molecular testing for the factor V Leiden and factor II G20210 A (prothrombin) mutations, protein C, protein S, antithrombin deficiency, presence of lupus anticoagulant, as well as anticardiolipin antibody titers. Patients aged less than 18 years, with confirmed deep vein thrombosis, and pregnant women were excluded. 95.5% were Caucasian, and 62.1% were female gender. Age ranged from 21-88 years. Molecular testing showed that 34.2% of patients were heterozygous for factor V Leiden, 23.6% were heterozygous for the factor II mutation, 7.8% had antithrombin deficiency, 2.6% had protein S deficiency, and 2.1% had protein C deficiency. Our study showed that hereditary and acquired thrombophilias are higher than previously expected and reported.

References

Sep 27, 1996·International Journal of Cancer. Journal International Du Cancer·G M KirbyM A Alaoui-Jamali
Mar 24, 1998·Journal of Vascular Surgery·R M BlumenbergJ Brennan
May 12, 1998·Journal of Vascular Surgery·J N HansonA Hingorani
Mar 20, 2003·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·José Maria Pereira de Godoy, Domingos Marcolino Braile
Feb 17, 2010·Annals of Internal Medicine·Hervé DecoususUNKNOWN POST (Prospective Observational Superficial Thrombophlebitis) Study Group

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Citations

Dec 7, 2019·Jornal Vascular Brasileiro·Marcelo José de AlmeidaWinston Bonnetti Yoshida

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