An unidentified macromolecular inhibitory constituent of calcium oxalate crystal growth in human urine

Urological Research
S SørensenS J Justesen

Abstract

We have detected and isolated a macromolecular constituent in normal human urine possessing calcium crystal growth inhibitory activity. The purification procedure consisted of two anion exchange chromatographies and one affinity chromatography. The crystal growth inhibitor was found to be heterogeneous in net charge as well as in size. It has not been identified. It is not an uronic acid-containing glycosaminoglycan, hitherto presumed to be responsible for the inhibitory activity. Whether an urinary fragment of inter-alpha-trypsin inhibitor is responsible has yet to be resolved.

References

Jul 2, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·R C BowyerR K McCulloch
Oct 15, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·A LigabueW G Robertson
May 1, 1978·Kidney International·H Fleisch
Jul 15, 1979·Analytical Biochemistry·G W JourdianJ Distler
Nov 1, 1977·The American Journal of Physiology·H Ito, F L Coe
Apr 1, 1986·Kidney International·M LopezJ I Scheinman
Jul 1, 1985·The Journal of Urology·K A EdyvaneV R Marshall
Oct 1, 1985·Kidney International·X MartinL H Smith
Aug 1, 1973·Analytical Biochemistry·N Blumenkrantz, G Asboe-Hansen
Jan 10, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·W G RobertsonB E Nordin
May 1, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·R L RyallV R Marshall
Jan 1, 1984·The Biochemical Journal·M StaunH Sjöström
Sep 1, 1984·Analytical Biochemistry·R H JuangJ C Su
Dec 9, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·J H Poulsen, M K Cramers
Jul 1, 1982·Analytical Biochemistry·U H StenmanM L Huhtala

❮ Previous
Next ❯

Citations

Dec 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M D McKeeS R Khan
Oct 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R L Ryall
Jul 31, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·L BorghiA Novarini
Jul 26, 2003·Protein Expression and Purification·Steen SørensenAnders H Johnsen
May 1, 1995·The Journal of Urology·P K Grover, M I Resnick
Sep 24, 1999·The Journal of Urology·S IidaS R Khan
Oct 1, 2003·International Journal of Urology : Official Journal of the Japanese Urological Association·Mitsuhiko OkuyamaSunao Yachiku
Feb 19, 1998·British Journal of Urology·C J DawsonR L Ryall
Mar 1, 1996·Journal of Neurosurgery·T KawaguchiN Tamaki
May 8, 1999·Journal of the American Society of Nephrology : JASN·S IidaS R Khan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.