Abstract
While hypersensitivity pneumonitis (HP) and asthma are usually recognized as different disease entities based on their different allergic mechanisms, they may have some connections. A previously healthy 54-year-old Japanese man with no history of allergic diseases was hospitalized due to fever and breathlessness. He had lived in an old musty wooden house. He was diagnosed with acute summer-type HP induced by Trichosporon asahii based on bilateral ground-glass opacities on chest computed tomography (CT), a high titer of serum anti-T. asahii antibody, an increased number of lymphocytes and a decreased CD4/CD8 ratio in bronchoalveolar lavage fluid (BALF) and lung pathology suggestive of HP. However, untypical increased eosinophils in BALF (25.2%) and infiltrative eosinophils around bronchial walls were observed. After systemic corticosteroid treatment was started, he recovered, and was discharged with oral prednisone. However, two weeks after returning to his former house, he had fever and severe cough, and was re-hospitalized. While chest CT showed no abnormal shadows indicating a worsening of HP, pulmonary function test revealed a typical obstructive defect and eosinophilic inflammation in his sputum. He spontaneously recovered ...Continue Reading
References
Jul 1, 1978·Chest·R M KarrJ E Salvaggio
Oct 1, 1991·The American Review of Respiratory Disease·M AndoM Tamura
Jan 1, 1990·The Journal of Allergy and Clinical Immunology·M AndoT Shinoda
Jul 6, 1985·Lancet·C K CampbellD W Mackenzie
Jan 1, 1988·Allergy·F LanderS Gravesen
May 1, 1985·Journal of Clinical Microbiology·E J McManus, J M Jones
Oct 1, 1983·The Journal of Allergy and Clinical Immunology·J L MaloC R Zeiss
Mar 1, 1994·Occupational and Environmental Medicine·D M HalpinA J Newman Taylor
Apr 1, 1997·Scandinavian Journal of Work, Environment & Health·J I KokkarinenE O Terho
May 30, 1998·Occupational Medicine·J B Buick, G R Todd
Apr 3, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Yoichi HirakataYukihiko Sugiyama
Oct 10, 2002·International Archives of Occupational and Environmental Health·Antti KarjalainenTimo Klaukka
Sep 3, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Robert L JacobsJacqueline J Coalson
May 17, 2007·Thorax·W RobertsonP S Burge
Nov 24, 2007·Allergy and Asthma Proceedings·Francisco Javier Ruiz-HornillosMaría Luisa Baeza Ochoa de Ocariz
May 22, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Nobuyuki KatayamaShinji Nakao
Dec 17, 2008·The American Journal of Pathology·Pieter BogaertJohan Grooten
Mar 25, 2009·Current Opinion in Allergy and Clinical Immunology·Kenneth D Rosenman
May 7, 2009·Allergy·D MiedingerM Labrecque
Jun 4, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ana VillarMaría-Jesús Cruz
Jan 15, 2019·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Elena SolanaXavier Muñoz
Mar 27, 2019·Multidisciplinary Respiratory Medicine·Martina SterclovaMartina Vasakova
Jun 1, 2019·American Journal of Respiratory and Critical Care Medicine·Martina VasakovaGanesh Raghu