PMID: 6538717Jan 1, 1984Paper

An unusual case of generalized ceroid-lipofuscinosis in a cynomolgus monkey

Veterinary Pathology
V JastyR E Hartnagel

Abstract

Histologic, histochemical, and electron microscopic studies of generalized ceroid-lipofuscinosis in a cynomolgus monkey are presented. Histologically, a wide variety of tissue cells contained numerous bright eosinophilic intracytoplasmic granules that varied in size from 0.5 micron to 4.0 microns in diameter. Histochemically, the granules gave a weakly positive reaction with periodic acid-Schiff and for lipids. They were weakly acid fast and capable of emitting autofluorescence. Ultrastructurally, the granules were single unit membrane-bound, and contained dense osmiophilic material with frequent concentric or fingerprint-type lamellar formation. The granules were different than hemofuscin, iron, and bilirubin. Tinctorially the granules were unique--they were bright red with hematoxylin and eosin and, thus, differed from typical age-related lipofuscin pigment.

References

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Citations

Jan 1, 1988·American Journal of Medical Genetics. Supplement·L Black, R K Pullarkat
May 26, 1998·American Journal of Medical Genetics·R T BronsonJ R Faust
Jan 1, 1988·American Journal of Medical Genetics. Supplement·H H GoebelF Malkusch
Jun 5, 2003·The Journal of Small Animal Practice·M KuwamuraK Sasai
Mar 1, 1988·Veterinary Pathology·R A Fiske, R W Storts
Mar 14, 2018·JFMS Open Reports·Crystal WhiteDaniel Sanchez-Masian
Jan 29, 2021·The Journal of Veterinary Medical Science·Akio SekiyaTakuya Doi

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