An unusual case of multi-recurrent herpes zoster (Hz): a case report

Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Vanda BostikovaPavel Bostik

Abstract

We report a case of multi-recurrent herpes zoster in a 53-year-old Caucasian woman treated repeatedly at the Faculty Hospital Hradec Kralove, Czech Republic over the years 2009 - 2011. Specific PCR methods targeting single nucleotide polymorphisms (SNPs) in open reading frames (ORF) 38, 54 and 62 were utilized to determine vaccine or wild type varicella-zoster (VZV) strains followed by SNPs analysis using two amplicons in ORF 22 and/or ORF 21/ORF 50. Additional genotyping in ORF 1, 6, 9 and 28 was subsequently performed due to the unusual results. Three sets of clinical specimens from one patient (from hospital visits 2, 3 and 4) were analyzed and the presence of an unusual wild-type strain of VZV was discovered. The VZV strain isolated from the lesions bears a combination of markers characteristic both for Mosaic 2 (M2) and European 1 (E1) wild-type VZV strains. This is the first report of atypical wild-type VZV strain circulating currently in Czech Republic.

References

Mar 1, 1996·Seminars in Dermatology·R G Kürzl
May 8, 2001·Archives of Virology. Supplementum·P S Larussa, A A Gershon

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Citations

Jan 18, 2017·Central European Journal of Public Health·Vanda BoštíkováPavel Boštík

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