An unusual cause for neonatal abstinence syndrome

Paediatrics & Child Health
Prashanth Murthy, Deborah Clark

Abstract

Neonatal abstinence syndrome (NAS) secondary to maternal drug use is a well-recognized clinical entity. We present a novel case of moderately severe NAS in a term infant whose mother was self-medicating with kratom tea. The baby required oral morphine for NAS. After 12 days in neonatal intensive care unit, she was discharged on oral morphine which was discontinued after 2 months. Kratom, a psychoactive herb with opioid activity, has traditionally been used as a stimulant to boost energy, cure cough, depression, pain, sickness and a substitute for opium. Although well known in South East Asia and Africa, this drug is less familiar to physicians in North America. It is undetectable by standard urine drug screening and is being sold as a legal herbal remedy. This is the first report of a newborn developing significant NAS after maternal use of kratom tea. We believe physicians should be aware of this 'new' risk to newborns.

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Citations

Oct 19, 2019·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·C Michael White
Aug 21, 2019·Journal of Psychopharmacology·John M CorkeryAmy Hendricks
Jan 30, 2020·Pain and Therapy·Steven C EastlackAlan D Kaye
Oct 14, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Somayyeh ZakerabasaliAzadeh Sayarifard
Apr 20, 2021·Frontiers in Psychiatry·Alessandro E VentoGeorgios D Kotzalidis
Nov 15, 2021·Journal of Clinical Pharmacology·Chad HartleyScott R Penzak

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