An unusual composite endometrial tumor combining papillary serous carcinoma and small cell carcinoma

The American Journal of Surgical Pathology
Ruthy Shaco-LevyIlana Ariel

Abstract

This is the first report in the English literature of a composite endometrial tumor composed of papillary serous carcinoma and small cell carcinoma. A 79-year-old woman underwent total abdominal hysterectomy and left salpingo-oophorectomy due to endometrial carcinoma. Grossly, the uterus was enlarged with an irregular and nodular serosal surface, thickened myometrium, and irregular endometrium. Microscopic examination revealed an endometrial carcinoma composed of papillary serous carcinoma and small cell carcinoma. There was a differential immunoreactivity between the two components: the cells of the papillary serous carcinoma were positive for cytokeratin, CA-125, CEA, and HER-2/Neu, whereas these markers were negative in the small cell carcinoma. Various neuroendocrine markers were positive in the small cell carcinoma and negative in the papillary serous carcinoma. Fluorescence in situ hybridization analysis using 4, 8, and 10 centromeric probes revealed hyperploidy (6-8 signals) in the small cell carcinoma cells. Most of the serous carcinoma cells were euploid, with scattered trisomies and tetrasomies of these chromosomes. The patient died of progressive disease 5 months after surgery. We suggest that the small cell carcinom...Continue Reading

References

Jan 1, 1985·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·P GrobenF Askin
Apr 1, 1994·The American Journal of Surgical Pathology·D G HuntsmanR E Scully
Jan 1, 1995·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·K H van HoevenM J Suhrland
Aug 27, 2002·Journal of Clinical Pathology·S Van EedenM-L F Van Velthuysen

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Citations

Oct 31, 2015·Pathology·Kyoung Min KimWoo Sung Moon
Feb 12, 2011·Seminars in Diagnostic Pathology·Diana Lim, Esther Oliva
Dec 1, 2009·Surgical Pathology Clinics·Robert A Soslow
Feb 3, 2007·Seminars in Oncology·Shellaine R FrazierTimothy S Loy
Jul 28, 2011·The Journal of Obstetrics and Gynaecology Research·Harunobu MatsumotoHisashi Narahara
Oct 16, 2015·Journal of Pathology and Translational Medicine·Yi Kyeong Chun
Jun 10, 2015·Cirugia y cirujanos·Oscar Zenón Rosas-GuerraHeriberto Garza-de la Llave
Jan 6, 2012·Journal of Korean Medical Science·Ki-Seok JangSam-Hyun Cho
Mar 6, 2016·The American Journal of Surgical Pathology·Cady E PocrnichAnais Malpica
Apr 14, 2016·Molecular and Clinical Oncology·Hisashi MasuyamaYuji Hiramatsu
Sep 2, 2018·Human Pathology·Georgia KarpathiouMichel Peoc'h
Nov 4, 2008·Archives of Pathology & Laboratory Medicine·Lorena PosliguaMichael T Deavers

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