PMID: 15222699Jun 30, 2004Paper

An unusual variant of the dorsal midbrain syndrome in MS: clinical characteristics and pathophysiologic mechanisms

Multiple Sclerosis : Clinical and Laboratory Research
Elliot M FrohmanTeresa C Frohman

Abstract

Patients with MS exhibit a broad diversity of ocular motor syndromes. We describe a patient with relapsing-remitting MS who developed an unusual variation of the dorsal midbrain syndrome, characterized by monocular convergent-retraction nystagmus in the right eye, accompanied by divergent-retraction nystagmus in the fellow eye upon attempted upward gaze. Examination also revealed a skew deviation with a left hyperdeviation and severe adduction limitation in the left eye during attempted right gaze. We propose that a left INO accounted for the inability of the left eye to adduct (and result in convergent-retraction) during attempted upward saccades. We consider the pathophysiologic mechanisms responsible for our observations and review important details of the dorsal midbrain ocular motor circuitry.

References

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Citations

Dec 1, 2007·International Ophthalmology Clinics·Janet C Rucker
Jun 28, 2017·Acta Neurologica Scandinavica·L PollakR Huna-Baron
Aug 25, 2006·Current Neurology and Neuroscience Reports·Andrew G Lee, Paul W Brazis
Oct 1, 2010·Continuum : Lifelong Learning in Neurology·Teresa C FrohmanElliot M Frohman
Oct 9, 2012·Current Opinion in Ophthalmology·Adnan M Subei, Eric Eggenberger

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