PMID: 9170129May 1, 1997Paper

An up-down Bayesian, defibrillation efficacy estimator

Pacing and Clinical Electrophysiology : PACE
A T ComposR E Ideker

Abstract

In both the clinic and the laboratory, efficacy estimators are used to estimate the shock strength required to achieve a given defibrillation success rate. In the clinic, efficacy estimators are used to estimate highly effective doses (i.e., the shock strength that defibrillates 95% of the time), in order to choose the setting for an ICD. Efficacy estimators are used in the laboratory to compare defibrillation techniques and configurations. Current efficacy estimators are inadequate because they are either difficult to use, can only estimate the shock strength that defibrillates 50% of the time, or do not yield desirable accuracy (low RMS error). This article presents a Bayesian estimation technique that forces the difference between successive test shock strengths (step-size) to be a fixed value after each measurement. Constraining the difference dramatically reduces the computational complexity of the up-down Bayesian method. This new, up-down Bayesian protocol can be used with up to 15 measurements to estimate the shock strength for any given success rate. Simulations show that the added constraint (fixed step-size) only slightly increases the rms error, as compared to the optimum Bayesian protocol. Our simulations also show...Continue Reading

References

Apr 1, 1992·Pacing and Clinical Electrophysiology : PACE·D HammelH H Scheld
Jun 1, 1992·Pacing and Clinical Electrophysiology : PACE·I Singer, D Lang
Jan 1, 1987·Pacing and Clinical Electrophysiology : PACE·M F RattesG J Klein
Sep 1, 1989·Pacing and Clinical Electrophysiology : PACE·M H LehmannK Jackson
Mar 1, 1993·IEEE Transactions on Bio-medical Engineering·R A MalkinR E Ideker

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Citations

Jun 18, 2010·Canadian Journal of Physiology and Pharmacology·Natnicha KanlopNipon Chattipakorn
Dec 17, 2003·Pacing and Clinical Electrophysiology : PACE·Yoshio YamanouchiPatrick J Tchou
Apr 20, 2004·Journal of Cardiovascular Electrophysiology·Dongxu Guan, Robert Malkin
Oct 6, 2006·IEEE Transactions on Bio-medical Engineering·Robert A MalkinJohn P Wikswo
Feb 25, 2000·Journal of Electrocardiology·R A Malkin
Jul 25, 2015·IEEE Transactions on Bio-medical Engineering·Danian JinYongqin Li
Mar 25, 1999·The American Journal of Cardiology·P C FotuhiR E Ideker
Oct 13, 2016·Pharmaceutical Statistics·Andrew P Grieve
Dec 10, 1999·Pacing and Clinical Electrophysiology : PACE·Y YamanouchiP J Tchou
May 30, 1998·Pacing and Clinical Electrophysiology : PACE·R A Malkin, E E Johnson
Aug 1, 1997·Journal of Cardiovascular Electrophysiology·R A MalkinR E Ideker
Jul 21, 1999·Journal of Cardiovascular Electrophysiology·R A MalkinR C Bernstein
Sep 2, 2000·Journal of Cardiovascular Electrophysiology·Y YamanouchiP J Tchou
Nov 5, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Amy L De JonghRobert A Malkin
Mar 1, 2012·The Open Biomedical Engineering Journal·Ron Davis, Robert Malkin

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