An update in the management of spinal metastases

Arquivos de neuro-psiquiatria
Andrei F JoaquimMark H Bilsky

Abstract

The best clinical treatment for spinal metastases requires an integrated approach with input from an interdisciplinary cancer team. The principle goals of treatment are maintenance or improvement in neurologic function and ambulation, spinal stability, durable tumor control, and pain relief. The past decade has witnessed an explosion of new technologies that have impacted our ability to reach these goals, such as separation surgery and minimally invasive spinal procedures. The biggest advance, however, has been the evolution of stereotactic radiosurgery that has demonstrated durable tumor control both when delivered as definitive therapy and as a postoperative adjuvant even for tumors considered markedly resistant to conventional external beam radiation. In this paper, we perform an update on the management of spinal metastases demonstrating the integration of these new technologies into a decision framework NOMS that assesses four basic aspects of a patient's spine disease: Neurologic, Oncologic, Mechanical Instability and Systemic disease.

References

Jan 1, 1978·Annals of Neurology·R W GilbertJ B Posner
Jun 1, 1982·Journal of Neurosurgery·R G PerrinB Aarabi
Jul 15, 1995·International Journal of Radiation Oncology, Biology, Physics·E Maranzano, P Latini
Jan 1, 1995·International Orthopaedics·J A Ortiz Gómez
Jan 22, 1998·The Annals of Thoracic Surgery·G L WalshJ A Roth
Dec 30, 1998·International Journal of Radiation Oncology, Biology, Physics·H KatagiriH Iwata
Aug 26, 1999·Seminars in Oncology Nursing·J D Bucholtz
Jan 5, 2000·Journal of Neuro-oncology·P D BrownD Schiff
Mar 29, 2000·CA: a Cancer Journal for Clinicians·R T GreenleeP A Wingo
Sep 1, 2000·Seminars in Oncology Nursing·P M Barse
Feb 27, 2001·Spine·K TomitaT Akamaru
May 8, 2001·Neurosurgical Review·U SchickR Lorenz
May 17, 2003·Science·Monica Garcia-BarrosRichard Kolesnick
Apr 27, 2005·International Journal of Radiation Oncology, Biology, Physics·Yoshiya YamadaSteven A Leibel
Jul 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dirk RadesSteven E Schild
Dec 5, 2006·International Journal of Radiation Oncology, Biology, Physics·Dirk RadesJuergen Dunst
Nov 26, 2009·Spine·Mark H BilskyShane Burch
Sep 3, 2010·Journal of Neurosurgery. Spine·Mark H BilskyTimothy R Kuklo
May 28, 2013·The Oncologist·Ilya LauferMark H Bilsky
Jul 12, 2013·Einstein·Andrei Fernandes JoaquimLeonardo Abdala Giacomini

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Citations

Jun 24, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ori BarzilaiMark H Bilsky
Feb 27, 2018·Neurosurgery·Ori BarzilaiMark H Bilsky
Dec 7, 2019·Spine·Erion Junior de AndradeAndrei Fernandes Joaquim
Jan 26, 2018·PloS One·Kazuya ShinmuraHiroyuki Tsuchiya
Jul 21, 2017·Revista da Associação Médica Brasileira·Andrei Fernandes JoaquimHelder Tedeschi
Apr 8, 2020·Molecular and Clinical Oncology·Kalliopi AlpantakiChristos Koutserimpas
Sep 4, 2020·BMC Musculoskeletal Disorders·Kazuya ShinmuraHiroyuki Tsuchiya
Oct 27, 2020·Journal of Craniovertebral Junction and Spine·Erion Junior de AndradeAndrei Fernandes Joaquim
Oct 23, 2020·Journal of Bone Oncology·Giuseppe Di PernaDiego Garbossa
Apr 6, 2021·Neurospine·Andrei Fernandes JoaquimK Daniel Riew
May 25, 2021·Clinical Case Reports·Babak MirzashahiSadegh Hasani Satehi

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