An update in the use of antibodies to treat glioblastoma multiforme

Autoimmune Diseases
Norma Y Hernández-PedroJulio Sotelo

Abstract

Glioblastoma is a deadly brain disease and modest improvement in survival has been made. At initial diagnosis, treatment consists of maximum safe surgical resection, followed by temozolomide and chemoirradiation or adjuvant temozolomide alone. However, these treatments do not improve the prognosis and survival of patients. New treatment strategies are being sought according to the biology of tumors. The epidermal growth factor receptor has been considered as the hallmark in glioma tumors; thereby, some antibodies have been designed to bind to this receptor and block the downstream signaling pathways. Also, it is known that vascularization plays an important role in supplying new vessels to the tumor; therefore, new therapy has been guided to inhibit angiogenic growth factors in order to limit tumor growth. An innovative strategy in the treatment of glial tumors is the use of toxins produced by bacteria, which may be coupled to specific carrier-ligands and used for tumoral targeting. These carrier-ligands provide tumor-selective properties by the recognition of a cell-surface receptor on the tumor cells and promote their binding of the toxin-carrier complex prior to entry into the cell. Here, we reviewed some strategies to impro...Continue Reading

References

Jan 1, 1977·Annual Review of Biochemistry·A M Pappenheimer
Jan 1, 1977·Vision Research·C R InglingB A Drum
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J K BatraC R King
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·U BrinkmannIra Pastan
Jan 1, 1988·Cancer Treatment and Research·D A Vallera, D E Myers
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J S HustonR Crea
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·R NishikawaH J Huang
Jun 1, 1993·Immunology Today·Ellen S VitettaJ W Uhr
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·K Chang, Ira Pastan
Jul 17, 1996·International Journal of Cancer. Journal International Du Cancer·E M RosenI D Goldberg
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·I A LorimerIra Pastan
Nov 15, 1997·Neurosurgery·Douglas W LaskeR J Youle
Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Katrin LamszusE M Rosen
Jun 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·J H SampsonD D Bigner
Feb 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M GordonD Adelman
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E OlsenJ Nichols
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·B CaoGeorge F Vande Woude
Oct 19, 2001·Medicinal Research Reviews·Peter TraxlerJ Zimmermann
Jun 28, 2002·Cancer Cell·Kari Alitalo, Peter Carmeliet
Apr 18, 2003·Cancer Immunology, Immunotherapy : CII·Ira Pastan
Jun 5, 2003·Cancer Cell·Kristian PietrasArne Ostman
Dec 3, 2003·Journal of Neuro-oncology·Michael Weaver, Douglas W Laske
Feb 3, 2005·Cell Research·Chong Feng Gao, George F Vande Woude
Mar 17, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Keren Paz, Zhenping Zhu
Oct 11, 2005·Neuro-oncology·Roger Abounader, John Laterra
Jan 13, 2006·Nature Clinical Practice. Oncology·Rakesh K JainJay S Loeffler
Jun 24, 2006·Nature Reviews. Cancer·Ira PastanRobert J Kreitman
Aug 25, 2006·Nature Reviews. Cancer·Kohzoh Imai, Akinori Takaoka
Sep 15, 2006·Mayo Clinic Proceedings·Ricardo H AlvarezJorge E Cortes
Oct 10, 2006·The AAPS Journal·Robert J Kreitman
Oct 25, 2006·Annual Review of Medicine·Ira PastanRobert J Kreitman
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tobias MartensKatrin Lamszus
Nov 1, 2006·Current Drug Targets·Robert J Kreitman, Ira Pastan
Dec 14, 2006·Advances in Experimental Medicine and Biology·Eduardo Díaz-Rubio
Apr 26, 2007·The American Journal of Pathology·Hiroko Ohgaki, Paul Kleihues
Dec 14, 2007·Cancer Biology & Therapy·Daniela MateiGeorge W Sledge
Feb 16, 2008·The Journal of Biological Chemistry·René JørgensenA Rod Merrill
Mar 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joseph Paul EderPatricia M LoRusso
Apr 7, 2009·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Robert J Kreitman
May 23, 2009·Cancer Science·Mrudula Mathew, Rama S Verma
Jun 6, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Bart NeynsJ De Greve
Oct 21, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alex A AdjeiRalph G Zinner
Oct 31, 2009·Journal of Pediatric Hematology/oncology·Larry HerreraJohn Schindler
Nov 21, 2009·Current Molecular Medicine·L MoserleS Indraccolo
Dec 1, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alba A BrandesMartin J van den Bent
Jan 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew M EvensLeo I Gordon
Jan 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer L SpratlinS Gail Eckhardt
Jan 22, 2010·Cancer Immunology, Immunotherapy : CII·Robert SarnovskyDavid J FitzGerald
Jan 26, 2010·Cellular Signalling·Georgios GiamasUwe Knippschild
Feb 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Jan DrappatzPatrick Y Wen
Apr 24, 2010·Nature Reviews. Immunology·Louis M WeinerShangzi Wang
May 12, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tracy BatchelorRakesh K Jain
May 18, 2010·Neuroscience Letters·Markus D SiegelinDario C Altieri
Jan 13, 2011·International Journal of Cancer. Journal International Du Cancer·Skjalg BruheimØystein Fodstad
Apr 23, 2011·Drug Discovery Today·Swati ChoudharyRama S Verma
Sep 29, 2011·Journal of Cancer Research and Clinical Oncology·Mario Orozco-MoralesJulio Sotelo
Nov 10, 2011·Toxins·Assaf Shapira, Itai Benhar
Mar 13, 2012·Journal of Neuro-oncology·David A ReardonHenry S Friedman
May 19, 2012·Expert Review of Anticancer Therapy·Mairéad G McNamara, Warren P Mason
Feb 1, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David A ReardonJohann de Bono
Feb 28, 2013·International Journal of Molecular Sciences·Wolf-Dieter JanthurChristoph Mamot
Aug 14, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tracy BatchelorMartin J van den Bent

Citations

May 27, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jing GeHai-Han Song
Jun 24, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiang YiAlexander V Kabanov
Oct 7, 2016·PloS One·Martin J HicksRonald G Crystal
Mar 24, 2012·Neurosurgery Clinics of North America·Jose A Carrillo, Claudia A Munoz
Dec 19, 2016·Expert Opinion on Drug Safety·S Harrison FarberJ H Sampson
Jan 18, 2018·Brain Sciences·Mayra PaolilloSergio Schinelli
Jun 10, 2017·Frontiers in Oncology·Kristina EllwangerMartin Treder

Methods Mentioned

BETA
xenografts
xenograft

Clinical Trials Mentioned

NCT01290263
NCT00895180
NCT00704288

Related Concepts

Blood Vessel
Brain Diseases
Drug Carriers
Glioblastoma
Glioma
Ligands
Neoplasms
Pathologic Neovascularization
Receptors, Cell Surface
Epidermal Growth Factor Receptor

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.