An Update of Palmitoylethanolamide and Luteolin Effects in Preclinical and Clinical Studies of Neuroinflammatory Events

Antioxidants
Marika CordaroRosalia Crupi

Abstract

The inflammation process represents of a dynamic series of phenomena that manifest themselves with an intense vascular reaction. Neuroinflammation is a reply from the central nervous system (CNS) and the peripheral nervous system (PNS) to a changed homeostasis. There are two cell systems that mediate this process: the glia of the CNS and the lymphocites, monocytes, and macrophages of the hematopoietic system. In both the peripheral and central nervous systems, neuroinflammation plays an important role in the pathogenesis of neurodegenerative diseases, such as Parkinson's and Alzheimer's diseases, and in neuropsychiatric illnesses, such as depression and autism spectrum disorders. The resolution of neuroinflammation is a process that allows for inflamed tissues to return to homeostasis. In this process the important players are represented by lipid mediators. Among the naturally occurring lipid signaling molecules, a prominent role is played by the N-acylethanolamines, namely N-arachidonoylethanolamine and its congener N-palmitoylethanolamine, which is also named palmitoylethanolamide or PEA. PEA possesses a powerful neuroprotective and anti-inflammatory power but has no antioxidant effects per se. For this reason, its co-ultram...Continue Reading

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Jul 31, 2020·International Journal of Molecular Sciences·Ramona D'AmicoRosanna Di Paola
Oct 25, 2020·BioFactors·Duraisamy KempurajAsgar Zaheer
Jan 21, 2021·Molecular and Cellular Biochemistry·Henrique Charlanti Reis AssunçãoLiliam Fernandes
Dec 19, 2020·International Journal of Molecular Sciences·Stefania Petrosino, Aniello Schiano Moriello
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Apr 4, 2021·Antioxidants·Silvia Dossena, Angela Marino
Jun 3, 2021·International Journal of Molecular Sciences·Paul ClaytonRuchitha Venkatesh

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Methods Mentioned

BETA
transgenic

Software Mentioned

Co
PEALut
ultra
ultra PEALut

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