An update on adjuvant interferon for melanoma

Cancer Control : Journal of the Moffitt Cancer Center
Richard J GrayJohn M Kirkwood

Abstract

Despite advances in the staging and surgical therapy of melanoma, patients with high-risk resected melanoma still have 5-year recurrence rates of 55% to 80% and 5-year survival rates as low as 25% to 70%. Effective adjuvant therapy is needed for this patient population. The authors review the literature regarding the use of interferon for the adjuvant therapy of resected melanoma. Low-dose adjuvant interferon regimens have not affected overall survival and have had an inconsistent effect on disease-free survival across different stage groupings. High-dose adjuvant interferon improved disease- free and overall survival in the E1684 and Intergroup E1694 trials. High-dose interferon regimens cause significant morbidity, but quality-adjusted years of life are greater with this therapy. Adjuvant high-dose interferon should be considered standard therapy for all high-risk melanoma patients expected to be able to tolerate the interferon and treated off protocol. In addition, this regimen should serve as the active control in future trials of alternative adjuvant therapies for these patients.

References

Nov 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E T CreaganL J Rodrigue
May 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P O LivingstonG Ritter
Feb 20, 1993·International Journal of Cancer. Journal International Du Cancer·W B HamiltonP O Livingston
Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M KirkwoodR H Blum
Oct 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B F ColeE Borden
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B E HillnerT J Smith
Feb 25, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A HåkanssonL Håkansson
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H PehambergerK Wolff
Jun 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M KirkwoodR H Blum
Feb 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K L KilbridgeR F Nease
Sep 12, 1957·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A ISAACS, J LINDENMANN

❮ Previous
Next ❯

Citations

Aug 28, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Marios DecatrisKen O'Byrne
May 30, 2003·Seminars in Cutaneous Medicine and Surgery·Larisa GeskinJohn M Kirkwood
Feb 19, 2014·International Journal of Molecular Medicine·Viola A Heinzelmann-SchwarzJames P Scurry
Feb 5, 2005·Cancer Immunology, Immunotherapy : CII·Pierosandro TagliaferriSalvatore Venuta
Nov 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Erika RichtigUNKNOWN European Cooperative Adjuvant Melanoma Treatment Study Group
Oct 30, 2013·Journal of Gynecologic Oncology·Qidan HuangJihong Liu
May 6, 2005·Journal of Lower Genital Tract Disease·Mary Ellen WechterTimothy M Johnson
Dec 4, 2003·Expert Opinion on Biological Therapy·Marko B Lens
Nov 19, 2003·Current Opinion in Oncology·Simrit Parmar, Leonidas C Platanias
Jun 12, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Arlhee DiazEnrique Montero
Jun 10, 2006·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·E RichtigJ Smolle
Jun 15, 2010·Clinics in Dermatology·Brooke T BaldwinNeil Alan Fenske

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.