An Update on Animal Models of Autoimmune Hepatitis: Are we There Yet?

Current Pharmaceutical Design
Urs Christen, Edith Hintermann

Abstract

Autoimmune hepatitis is characterized by a progressive destruction of the liver parenchyma and a chronic fibrosis. Although the major targets of this autoimmune-mediated disease have been identified more than two decades ago, the current treatment of autoimmune hepatitis is still based on traditional therapies including a glucocorticoid treatment. One reason for this impasse is the limited availability of reliable animal models that reflect the clinical features of autoimmune hepatitis and allow for the identification of critical factors driving the autoimmune destruction and the evaluation of innovative therapies. However, the status of the liver as an immune privileged organ harbouring many immunosuppressing mechanisms hampers the development of such models. Here we will review the past and present attempts to develop a consistent animal model for autoimmune hepatitis.

Citations

Dec 6, 2016·International Journal of Molecular Sciences·Urs Christen, Edith Hintermann
Dec 14, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jinling HuangChen Dong
Mar 6, 2018·Frontiers in Immunology·Urs Christen, Edith Hintermann
Mar 19, 2021·Drug Development Research·Qiao LingYingju Liu
Feb 13, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tingting WangLi Yang

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