Abstract
Myofascial pain syndrome (MPS) is a common chronic pain condition that is characterized by distinct "trigger points." Despite current treatments with physical therapy, analgesics, anti-depressants and trigger-point injections, myofascial pain remains a challenging chronic pain condition in clinical practice. Botulinum toxin A (BTX-A) can cause prolonged muscle relaxation through inhibition of acetylcholine release. It may offer some advantages over the current treatments for MPS by providing a longer sustained period of pain relief. Despite numerous clinical trials, the efficacy of BTX-A in alleviating MPS is not well-established due to mixed results from recent clinical trials. Active trigger points are associated with referred pain and greatly impact many aspects of activities of daily living, mood, and health status. This review is designed to analyze the clinical trials regarding the efficacy of BTX-A injection of active trigger points as a treatment for MPS. The literature referenced was obtained via a computer search with Google Scholar, Pubmed, Medline and EMbase. Our search terms included "Botulinum toxin," "myofascial pain," "trigger points," "myofascial trigger points," "chronic pain." Additional references were retri...Continue Reading
References
Dec 1, 1985·Oral Surgery, Oral Medicine, and Oral Pathology·J R FrictonR Siegert
Sep 1, 1994·The Clinical Journal of Pain·J L Quintner, M L Cohen
Oct 1, 1994·Pain·W P CheshireJ D Mann
Jan 1, 1997·Regional Anesthesia·S C Han, P Harrison
Aug 15, 1998·Spine·A H WheelerS S Gretz
Jul 8, 1999·The New England Journal of Medicine·M Hallett
Apr 12, 2000·Headache·B J Freund, M Schwartz
Jul 7, 2001·Archives of Physical Medicine and Rehabilitation·T M Cummings, A R White
Dec 4, 2001·Pain·A H WheelerS S Gretz
Jan 5, 2002·Expert Opinion on Investigational Drugs·G E BorodicE A Johnson
Feb 7, 2003·The Clinical Journal of Pain·Joseph C Arezzo
Jul 4, 2003·The Clinical Journal of Pain·J De AndrésA Minguez
Feb 5, 2004·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·David G Simons
Jul 17, 2004·European Neurology·J M S Pearce
Jul 30, 2005·Anesthesiology·F Michael FerranteLaurence King
Oct 6, 2005·Pain·Corrie L GraboskiRobert S Burnham
Jun 6, 2006·Pain·Hartmut GöbelUNKNOWN Dysport myofascial pain study group
Jul 26, 2006·Neurology·E QeramaT S Jensen
Aug 2, 2007·Journal of Cell Science·Jianghui MengJ Oliver Dolly
Jan 1, 2008·Archives of Physical Medicine and Rehabilitation·Jay P ShahLynn H Gerber
Jan 11, 2008·BJU International·Alvaro LucioniDavid E Rapp
Jun 23, 2009·Journal of Rehabilitation Medicine·Paul McCroryAndrew Hughes
Sep 8, 2009·Pharmacology, Biochemistry, and Behavior·Lidija Bach-Rojecky, Zdravko Lacković
Feb 23, 2010·Medicina oral, patología oral y cirugía bucal·Eduardo Vázquez-DelgadoCosme Gay-Escoda
Aug 24, 2010·Pain·Parisa GazeraniBrian E Cairns
Jun 23, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Reiner BeneckeUNKNOWN Dysport myofascial pain study group
Oct 5, 2011·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Jeffrey J BallynsSiddhartha Sikdar
Feb 7, 2012·Clinical Rehabilitation·John Walter DunneUNKNOWN Multicentre Study Group
Jul 3, 2013·PM & R : the Journal of Injury, Function, and Rehabilitation·Lynn H GerberJay Shah
Citations
Aug 6, 2014·Current Pain and Headache Reports·Deepak SharanRameshkumar Ranganathan
Nov 12, 2015·Toxins·Sabine PellettRoshni Ramachandran
Jul 3, 2015·Toxins·Domenico IntisoFilomena Di Rienzo
Nov 2, 2016·Journal of Pain & Palliative Care Pharmacotherapy·Joaquín Cartagena-SevillaJuan P Vicente-Villena
Jun 14, 2018·Dental press journal of orthodontics·Ambrosina Michelotti
Jul 11, 2019·Regional Anesthesia and Pain Medicine·Hannah K TandonBarbara I Karp
Sep 5, 2018·Toxins·Da-Ye Kim, Jae Min Kim
Nov 19, 2020·International Journal of Environmental Research and Public Health·Michał Wendt, Małgorzata Waszak
Apr 15, 2021·World Journal of Clinical Cases·Qi-Wang CaoDong Huang