An update on botulinum toxin A injections of trigger points for myofascial pain

Current Pain and Headache Reports
Jon Y Zhou, Dajie Wang

Abstract

Myofascial pain syndrome (MPS) is a common chronic pain condition that is characterized by distinct "trigger points." Despite current treatments with physical therapy, analgesics, anti-depressants and trigger-point injections, myofascial pain remains a challenging chronic pain condition in clinical practice. Botulinum toxin A (BTX-A) can cause prolonged muscle relaxation through inhibition of acetylcholine release. It may offer some advantages over the current treatments for MPS by providing a longer sustained period of pain relief. Despite numerous clinical trials, the efficacy of BTX-A in alleviating MPS is not well-established due to mixed results from recent clinical trials. Active trigger points are associated with referred pain and greatly impact many aspects of activities of daily living, mood, and health status. This review is designed to analyze the clinical trials regarding the efficacy of BTX-A injection of active trigger points as a treatment for MPS. The literature referenced was obtained via a computer search with Google Scholar, Pubmed, Medline and EMbase. Our search terms included "Botulinum toxin," "myofascial pain," "trigger points," "myofascial trigger points," "chronic pain." Additional references were retri...Continue Reading

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Citations

Aug 6, 2014·Current Pain and Headache Reports·Deepak SharanRameshkumar Ranganathan
Nov 2, 2016·Journal of Pain & Palliative Care Pharmacotherapy·Joaquín Cartagena-SevillaJuan P Vicente-Villena
Jun 14, 2018·Dental press journal of orthodontics·Ambrosina Michelotti
Jul 11, 2019·Regional Anesthesia and Pain Medicine·Hannah K TandonBarbara I Karp
Nov 19, 2020·International Journal of Environmental Research and Public Health·Michał Wendt, Małgorzata Waszak
Apr 15, 2021·World Journal of Clinical Cases·Qi-Wang CaoDong Huang

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