An update on inhibitors of human 14 kDa Type II s-PLA2 in development

Current Pharmaceutical Design
D M Springer

Abstract

Recent progress in the development of inhibitors of human Type II s-PLA2 as potential anti-inflammatory agents is presented. While many companies have curtailed their efforts in the PLA2 area, Eli Lilly and Shionogi are continuing to advance LY-315920 (S-5920) as a potential treatment for sepsis and other diseases that have an inflammatory component. The Lilly developmental effort leading to LY-315920 is extensively reviewed, as well as the current status of other small molecular weight inhibitors of Type II s-PLA2 that have been reported to be in late-stage development

Citations

Sep 13, 2006·Journal of Neuroinflammation·Timothy J CunninghamLihua Yao
Feb 20, 2016·Environmental Science & Technology·Ting-Ting FanDonald L Sparks
Jun 5, 2003·Expert Opinion on Therapeutic Targets·Kieran F ScottKatherine J Bryant
Mar 10, 2016·Anais Da Academia Brasileira De Ciências·Bhadrapura Lakkappa Dhananjaya, Sudharshan Shivalingaiah
Mar 5, 2003·Chembiochem : a European Journal of Chemical Biology·Karl A HansfordDavid P Fairlie
May 17, 2003·Nature Reviews. Drug Discovery·John C Marshall
Mar 31, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Luigi MarianiMassimo Gion

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