An update on LDL apheresis for nephrotic syndrome

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Rupesh Raina, Vinod Krishnappa

Abstract

Low-density lipoprotein (LDL) apheresis has been used increasingly in clinical practice for the treatment of renal diseases with nephrotic syndrome (NS), specifically focal segmental glomerulosclerosis (FSGS). Persistent hyperlipidemia for prolonged periods is nephrotoxic and leads to chronic progressive glomerular and tubulointerstitial injury. Effective management of hyperlipidemia with HMG-CoA reductase inhibitors or LDL apheresis in drug-resistant NS patients may prevent the progression of renal disease and, in some patients, resolution of NS symptoms. Available literature reveals beneficial effects of LDL apheresis for NS refractory to drug therapy. Here we update on the current understanding of lipid nephrotoxicity and application of LDL apheresis to prevent progression of renal diseases.

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Citations

Nov 30, 2019·Journal of Clinical Apheresis·Randolf HardersenAnders Hovland
Jul 31, 2020·Expert Opinion on Emerging Drugs·Howard Trachtman
Nov 7, 2019·Case Reports in Nephrology·Hamza Naciri BennaniRachel Tetaz
Jul 2, 2020·International Journal of Nephrology and Renovascular Disease·Kohsuke TeradaYukinao Sakai
Jun 30, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lokesh ShahJoshua J Zaritsky
Mar 13, 2020·International Journal of Nephrology and Renovascular Disease·Samuel N UwaezuokeNgozi R Mbanefo
May 10, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Agnes TrautmannUNKNOWN International Pediatric Nephrology Association
Sep 19, 2020·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Rupesh RainaRonith Chakraborty
Aug 28, 2021·Journal of Personalized Medicine·Mengyuan GeAlessia Fornoni
Aug 29, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mohammad Al-MousilyKatherine Twombley
Nov 19, 2021·Molecular and Cellular Pediatrics·Agnes HacklLutz Thorsten Weber

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